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CD8A — IL17D

Text-mined interactions from Literome

Hisada et al., Cancer Res 2004 (Colonic Neoplasms) : The antitumor activity of IL-27 was almost diminished in nude mice, and depletion of CD8 ( + ) T cells and neutralization of IFN-gamma in immunocompetent mice reduced greatly the antitumor activity
Mittal et al., Immunol Cell Biol 2012 : Here, we show that the IL-27 receptor is expressed on human CD8 ( + ) T cells and stimulation of human naïve CD8 ( + ) T cells in the presence of IL-27 leads to an increase in IL-21 and interferon ( IFN ) -? production ... IL-21 induction in IL-27 stimulated human CD8 ( + ) T cells correlates specifically with expression of the transcription factor T-bet
Liu et al., Eur J Immunol 2013 : However, the exact mechanisms of how IL-27 enhances antitumor CD8 ( + ) T-cell responses remain unclear