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CCK — PTK2

Text-mined interactions from Literome

Kiehne et al., Pancreatology 2002 (Pancreatic Neoplasms) : Differential activation of p42ERK2 and p125FAK by cholecystokinin and bombesin in the secretion and proliferation of the pancreatic amphicrine cell line AR42J ... p42ERK2 and p125FAK were activated by cholecystokinin and bombesin with maximum stimulation at concentrations above 10 nM
Pace et al., J Biol Chem 2003 : Phosphospecific site tyrosine phosphorylation of p125FAK and proline-rich kinase 2 is differentially regulated by cholecystokinin receptor type A activation in pancreatic acini
Taniguchi et al., Oncogene 1994 : In contrast, tyrosine phosphorylation of p125FAK ( focal adhesion kinase ) was induced by CCK-8 but not by PDGF
Yoshida et al., Am J Physiol 1997 : CCK-6 and CCK-5 did not stimulate PTK activity, whereas CCK-4 evoked a 3.2- to 5.3-fold increase over basal
García et al., Biochem J 1997 : Cholecystokinin stimulated tyrosine phosphorylation of p125FAK and paxillin is mediated by phospholipase C-dependent and -independent mechanisms and requires the integrity of the actin cytoskeleton and participation of p21rho ... CCK-8 stimulated phosphorylation of p125(FAK) and paxillin reached a maximum within 2.5 min ... Treatment with Clostridium botulinum C3 transferase, which inactivates p21 ( rho ), caused significant inhibition of CCK-8 stimulated p125(FAK) and paxillin phosphorylation
Rosado et al., Biochim Biophys Acta 1998 : Pretreatment with genistein, a tyrosine kinase inhibitor, decreased CCK-8 stimulated tyrosine phosphorylation of p125FAK and paxillin and CCK-8 stimulated amylase secretion by more than 60 %, raising the possibility that tyrosine phosphorylation of these two proteins could be important in the ability of CCK-8 to stimulate amylase release ... Pretreatment with different concentrations of cytochalasin D, an actin cytoskeleton assembly inhibitor, completely inhibited CCK-8 stimulated tyrosine phosphorylation of p125FAK and paxillin without having any effect on either the potency or efficacy of CCK-8 at stimulating amylase release ... However, our results suggest Rho is involved in the CCK-8 stimulation of amylase release by a parallel pathway to its involvement in the CCK-8 stimulated tyrosine phosphorylation of p125FAK and paxillin