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ACAN — BMP7

Text-mined interactions from Literome

Tsai et al., J Cell Biochem 2003 : OP-1 also stimulated aggrecan mRNA expression
Yeh et al., Biochem Biophys Res Commun 2004 : To investigate transcriptional regulation of the aggrecan gene by OP-1 , we constructed a clone containing a 1 kb region of the 5'-upstream sequence of the mouse aggrecan gene fused to the promoter-less luciferase reporter gene in pGL2-Basic vector
Li et al., J Spinal Disord Tech 2004 : The results of this study show that in rat intervertebral disc cells, BMP-2 increases aggrecan and collagen type II mRNA expression and decreases versican gene expression
Söder et al., Arthritis Rheum 2005 : The inhibition of autocrine OP-1 caused a striking decrease in aggrecan gene expression, in total proteoglycan content accumulated in cartilage matrix, and in the ability of chondrocytes to newly synthesize proteoglycans
Estes et al., Arthritis Rheum 2006 : Most notably, BMP-6 up-regulated AGC1 and COL2A1 expression by an average of 205-fold and 38-fold, respectively, over day-0 controls, while down regulating COL10A1 expression by approximately 2-fold
Lincoln et al., Dev Biol 2006 : In multiple assays of cells from prefused endocardial cushions, BMP2 is sufficient to activate Smad1/5/8 phosphorylation and induce sox9 and aggrecan expression, while FGF4 treatment increases phosphorylated MAPK ( dpERK ) signaling and promotes expression of scleraxis and tenascin
Rui et al., J Orthop Res 2013 (Tendinopathy) : In conclusion, BMP-2 promoted GAG deposition, aggrecan expression, and enhanced non-tenocyte differentiation of TDSCs in vitro