Gene interactions and pathways from curated databases and text-mining

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ABL1 — BAX

Text-mined interactions from Literome

Keeshan et al., Leukemia 2001 : Despite the drug-resistant phenotype, high Bcr-Abl levels concomitantly increased the expression of p53, p21, Bax and down-regulated Bcl-2
Keeshan et al., Leukemia 2002 : High Bcr-Abl expression prevents the translocation of Bax and Bad to the mitochondrion ... This study demonstrates that the subcellular translocation of Bax and Bad can be regulated by elevated Bcr-Abl expression and this may be a key event in the abrogation of an apoptotic response following a cytotoxic insult
Kim et al., Cell Death Differ 2013 : The expression kinetics of TAp63, c-Abl and TAp73 suggest that cisplatin activates TAp63 dependent expression of c-Abl and TAp73 and, in turn, the activation of TAp73 by c-Abl induced BAX expression