Lynch et al., J Biol Chem 2005
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RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79 mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells
Houslay et al., Biochem Soc Trans 2005
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Beta-arrestin recruited phosphodiesterase-4 desensitizes the AKAP79/PKA mediated switching of beta2-adrenoceptor signalling to activation of ERK Tao et al., Journal of molecular signaling 2008
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Suppression of the expression of AKAP5 in either A431 cells or HEK293 cells leads to loss of the ability of the beta2-adrenergic receptor to activate Erk1,2