Gene interactions and pathways from curated databases and text-mining
CASP8: top 25 interacting genes (chr2:202122753-202152434)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only CASP8-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
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Less-frequently mentioned interactions with CASP8, not among the Top 25
Other genes interacting with CASP8. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

AKT3 ▸ XIAP ▸ IL1B ▸ FASLG ▸ MAPK3 ▸ DIABLO ▸ IL1A ▸
BCL6 ▸ BCL5 ▸ BCL9 ▸ BCL3 ▸ EPHB2 ▸ MAPK1 ▸ IRF6 ▸
MAPK4 ▸ MAPK14 ▸ MAPK12 ▸ MAPK8 ▸ MAPK13 ▸ MAPK10 ▸ MAPK7 ▸
MAPK15 ▸ MAPK9 ▸ MAPK11 ▸ MAPK6 ▸ IFNG ▸ CASP3 ▸ APAF1 ▸
CAPN1 ▸ CAPN10 ▸ FADD ▸ CAPN7 ▸ CAPN3 ▸ CAPN15 ▸ IL18 ▸
CAPN13 ▸ CAPN11 ▸ CAPN8 ▸ CAPN12 ▸ CAPN5 ▸ CAPN6 ▸ CAPN14 ▸
CAPN9 ▸ CAPN2 ▸ STS ▸ ASIP ▸ DNTT ▸ MCL1 ▸ MMP9 ▸
MMP2 ▸ MMP14 ▸ MMP12 ▸ MMP3 ▸ MMP11 ▸ MMP15 ▸ MMP1 ▸
MMP10 ▸ CDKN1A ▸ MMP20 ▸ MMP24 ▸ MMP25 ▸ MMP13 ▸ MMP27 ▸
MMP21 ▸ NLRP3 ▸ MMP19 ▸ MMP7 ▸ MMP8 ▸ MMP16 ▸ MMP17 ▸
MMP28 ▸ MMP26 ▸ JUN ▸ CASP9 ▸ PDCD11 ▸ PDCD5 ▸ RNF19A ▸
CFLAR ▸ CASP12 ▸ PDCD4 ▸ PDCD7 ▸ PDCD2 ▸ PDCD10 ▸ PDCD6 ▸
PDCD1 ▸ CYCS ▸ NA ▸ CASP1 ▸ IGF1 ▸ CASP2 ▸ ANXA5 ▸
INS ▸ PCBD1 ▸ AHSA1 ▸ TGFB1 ▸ CASP6 ▸ HLA-DRB1 ▸ MPZ ▸
PI3 ▸ NLRC4 ▸ CASP7 ▸ PIK3R1 ▸ CASP16 ▸ PIK3CA ▸ CASP5 ▸
EPO ▸ CASP4 ▸ CASP14 ▸ CASP10 ▸ DDIT3 ▸ PRKCD ▸ TNFRSF1A ▸
PRDX2 ▸ NOS2 ▸ DISC2 ▸ TAT ▸ DFFA ▸ DISC1 ▸ PCNA ▸
CRK ▸ GRAP2 ▸ MYLIP ▸ IL6 ▸ GSK3B ▸ EGF ▸ IL4 ▸
CTSB ▸ BIRC2 ▸ CAST ▸ IL8 ▸ CTNNB1 ▸ EIF2AK2 ▸ NOS1 ▸
IRF1 ▸ SOD1 ▸ VEGFA ▸ PTGS2 ▸ BID ▸ NGF ▸ LEP ▸
DFFB ▸ PAK2 ▸ HGF ▸ ABL1 ▸ APP ▸ P2RX7 ▸ DNASE1 ▸
DNASE2 ▸ ROCK1 ▸ ALPI ▸ BDNF ▸ MYC ▸ CAT ▸ IFNB1 ▸
CDK2 ▸ SOD2 ▸ RIPK1 ▸ APEH ▸ TCF4 ▸ IL16 ▸ IFI27 ▸
BCR ▸ FOS ▸ MAP3K1 ▸ TCF25 ▸ TLR2 ▸ IL10 ▸ RAC1 ▸
NFKBIA ▸ TCF24 ▸ NOD2 ▸ TCF15 ▸ IL2 ▸ UPK3B ▸ MAP2K1 ▸
TCF19 ▸ TCF3 ▸ CSF2 ▸ HTRA2 ▸ TCF21 ▸ CTSD ▸ NOS3 ▸
NOX1 ▸ TCF23 ▸ TCF20 ▸ CA2 ▸ TCF12 ▸ BMP1 ▸ TCF7 ▸
HDAC2 ▸ ARSK ▸ CSF3 ▸ APOB ▸ STAT1 ▸ POLDIP2 ▸ NLRP1 ▸
SOD3 ▸ PRKDC ▸ AIM2 ▸ BMP4 ▸ TLR4 ▸ ADCYAP1 ▸ ATP5O ▸
BIRC7 ▸ HSPA5 ▸ MAGT1 ▸ HDAC1 ▸ ITIH4 ▸ LMNB1 ▸ FGF2 ▸
NOX4 ▸ CD8A ▸ CDC73 ▸ GAL ▸ BAD ▸ BIRC3 ▸ TLR3 ▸
SMPD2 ▸ TLR5 ▸ LEO1 ▸ HSPB1 ▸ RB1 ▸ NOX5 ▸ TLR7 ▸
NOX3 ▸ PDLIM7 ▸ BMP15 ▸ GZMB ▸ IL33 ▸ BMP7 ▸ HMGB1 ▸
ENDOG ▸ BMP5 ▸ IL11 ▸ IL3 ▸ RIPK2 ▸ NOD1 ▸ SNAP25 ▸
BMP6 ▸ IL15 ▸ HPR ▸ CARD8 ▸ BMP2 ▸ IL5 ▸ PML ▸
STAT3 ▸ PPP2CA ▸ CTR9 ▸ PAF1 ▸ BMP10 ▸ TRAF6 ▸ AGTR1 ▸
CD79A ▸ PPP2R2B ▸ MST1 ▸ PPP2R1A ▸ BMP3 ▸ KRT18 ▸ CDK5 ▸
WDR61 ▸ LPA ▸ IL24 ▸ CCDC88A ▸ TLR8 ▸ CDC6 ▸ MAP2K2 ▸
IL21 ▸ RBBP7 ▸ MET ▸ RAD51 ▸ TLR1 ▸ CSE ▸ CREB3 ▸
PGP ▸ EGFR ▸ BIRC6 ▸ RBBP4 ▸ TXN ▸ IL20 ▸ PRNP ▸
BOC ▸ LMNB2 ▸ CD4 ▸ HIF1A ▸ IGF2 ▸ GP5 ▸ JAK2 ▸
PTX3 ▸ WAS ▸ ICAM1 ▸ GP2 ▸ CXCL9 ▸ TNFRSF1B ▸ CREB5 ▸
PTX4 ▸ GP6 ▸ GSN ▸ APC ▸ EIF2S1 ▸ SYK ▸ PPARA ▸
HTT ▸ NPS ▸ PLCG1 ▸ ANXA1 ▸ GP9 ▸ CREB1 ▸ CDH1 ▸
RIPK3 ▸ TLR10 ▸ ARID1A ▸ MUC19 ▸ CARD11 ▸ ACHE ▸ ANGPT2 ▸
KDR ▸ RRAS ▸ IL22 ▸ SMARCC2 ▸ HMOX1 ▸ IL13 ▸ MUC4 ▸
MUC1 ▸ IRF3 ▸ CCND1 ▸ SMARCB1 ▸ SMARCD1 ▸ TOP1 ▸ IKBKB ▸
ACTL6A ▸ MUC21 ▸ IL19 ▸ MSC ▸ SMPD1 ▸ IL34 ▸ HSPD1 ▸
ROCK2 ▸ SMARCA4 ▸ TLR9 ▸ SMARCD2 ▸ MDM2 ▸ MUC13 ▸ MUC2 ▸
CD79B ▸ TLR6 ▸ ABCC6 ▸ IL27 ▸ RENBP ▸ CDA ▸ RAF1 ▸
MUC12 ▸ IL9 ▸ IL25 ▸ FOXO3 ▸ IL26 ▸ MUC20 ▸ SYT1 ▸
MUC17 ▸ PLD1 ▸ GATA1 ▸ IL32 ▸ MUC22 ▸ SMARCA2 ▸ MUC15 ▸
IL31 ▸ PAK1 ▸ SMARCE1 ▸ BRCA1 ▸ STX1A ▸ PPARG ▸ IL37 ▸
BECN1 ▸ MUC7 ▸ CARD9 ▸ UCN ▸ CDK8 ▸ MUC6 ▸ TRAF1 ▸
SMARCC1 ▸ CARD6 ▸ MUC8 ▸ LYN ▸ CCL2 ▸ MUC16 ▸ IL7 ▸
MEFV ▸ GDNF ▸ BIRC5 ▸ CEP152 ▸ GRK5 ▸ LAT ▸ CEP164 ▸
WNT1 ▸ PIDD ▸ CEP120 ▸ CEP170 ▸ CEP41 ▸ NPM1 ▸ RASA1 ▸
SP1 ▸ GRK6 ▸ PTHLH ▸ HUNK ▸ CDK4 ▸ VIM ▸ ADIPOQ ▸
ARC ▸ ARSA ▸ CEP89 ▸ SKP1 ▸ SLC9A1 ▸ TARDBP ▸ SLCO6A1 ▸
PRKACG ▸ PRKCG ▸ PTK2 ▸ HIP1 ▸ IRF2 ▸ SETBP1 ▸ SLC17A5 ▸
CEP350 ▸ PSMD10 ▸ CEP97 ▸ PTEN ▸ TCHP ▸ CEP250 ▸ IRF5 ▸
HSF1 ▸ GUCY2D ▸ CEP128 ▸ HIST2H2BE ▸ HSP90AA1 ▸ CEP72 ▸ CARD18 ▸
NUP153 ▸ PRKAR2B ▸ CEP68 ▸ CALM3 ▸ MAP2K3 ▸ GRK1 ▸ MPST ▸
CEP63 ▸ CARD14 ▸ LYPLA1 ▸ GRB14 ▸ CEP55 ▸ PLOD2 ▸ CEP85 ▸
IL1RN ▸ E2F1 ▸ NUP62 ▸ PEA15 ▸ FOXO1 ▸ DST ▸ CEP192 ▸
PRKAR1A ▸ IGF1R ▸ CEP76 ▸ PRKCA ▸ MAP2K5 ▸ VCP ▸ PRKACB ▸
CEP19 ▸ EHMT1 ▸ MAP2K4 ▸ IRF4 ▸ PANX1 ▸ IKBKG ▸ PRKAR2A ▸
CARD17 ▸ GRB10 ▸ PRKAR1B ▸ CEP44 ▸ MEPE ▸ DERL1 ▸ CEP95 ▸
CEP135 ▸ GRB7 ▸ CEP70 ▸ VDAC1 ▸ H2AFX ▸ ALB ▸ CEP57 ▸
NUP214 ▸ SETD2 ▸ PXN ▸ CD47 ▸ MIF ▸ ALK ▸ GRB2 ▸
DES ▸ CCR7 ▸ CUL1 ▸ CEP290 ▸ CD40 ▸ ATG5 ▸ PTBP1 ▸
BCL2L12 ▸ EPX ▸ BACE1 ▸ MAP2K6 ▸ PSEN1 ▸ TRAF3 ▸ NUP210 ▸
TNFRSF10A ▸ ME2 ▸ BIRC8 ▸ CARD16 ▸ PLD2 ▸ SOAT1 ▸ CEP78 ▸
ANGPT1 ▸ GRK7 ▸ ELAVL1 ▸ SEC14L2 ▸ MAP2K7 ▸ CEP104 ▸ CARD10 ▸
CEP112 ▸ NPY6R ▸ GRK4 ▸ VIMP ▸ TRAF2 ▸ ANXA6 ▸ E2F3 ▸
FOXP3 ▸ FUT1 ▸ PRKAG2 ▸ CDK19 ▸ CCR10 ▸ ODC1 ▸ SERPINA1 ▸
CA8 ▸ RANBP2 ▸ XRCC6 ▸ TET3 ▸ MED24 ▸ APOE ▸ MED25 ▸
PAEP ▸ EIF4G3 ▸ MED23 ▸ DAP3 ▸ NAIP ▸ AIP ▸ CALB1 ▸
KLKB1 ▸ SPP1 ▸ CALR ▸ CTNNBL1 ▸ APEX1 ▸ CCNC ▸ JAK1 ▸
SMAD7 ▸ CISH ▸ QRICH1 ▸ MT4 ▸ CYR61 ▸ HIPK2 ▸ KLK3 ▸
SLPI ▸ PRKAA2 ▸ GYS1 ▸ SHC1 ▸ NAB1 ▸ SDS ▸ DYRK1A ▸
MED26 ▸ TRAF4 ▸ CDK15 ▸ TGM2 ▸ HDAC4 ▸ TAC1 ▸ PTCH1 ▸
GLI1 ▸ COP ▸ ACAD8 ▸ MT3 ▸ PDGFB ▸ MED8 ▸ MAP3K7 ▸
PMEL ▸ JAK3 ▸ CDK14 ▸ MED17 ▸ ITCH ▸ PRKAB1 ▸ CDK16 ▸
CCR6 ▸ EMP3 ▸ DIDO1 ▸ IAPP ▸ IARS ▸ FHIT ▸ SMAD3 ▸
CXCL17 ▸ IFNA2 ▸ S100A12 ▸ TYR ▸ GJA1 ▸ PRKAG1 ▸ RIPK4 ▸
TNFRSF10B ▸ NACA ▸ NLRC5 ▸ CDCA5 ▸ CSF1 ▸ RHO ▸ MED4 ▸
APOBEC3D ▸ BAG3 ▸ NUP43 ▸ TIMP3 ▸ PRKAA1 ▸ QRICH2 ▸ RAD17 ▸
CD2 ▸ PLD5 ▸ ETS1 ▸ GHSR ▸ NUAK1 ▸ EEF1A2 ▸ EIF4G2 ▸
MTOR ▸ SERP2 ▸ TGFB3 ▸ PRG4 ▸ ERVK-6 ▸ SREBF1 ▸ DLG1 ▸
NLRP5 ▸ MICE ▸ RBL2 ▸ PAN3 ▸ CENPK ▸ CHUK ▸ CDC42 ▸
UCP2 ▸ RAD52 ▸ RAB5A ▸ CDK1 ▸ CTSL ▸ RAD18 ▸ RAD1 ▸
NANOG ▸ WNK1 ▸ E2F2 ▸ EDNRA ▸ IDO1 ▸ XAF1 ▸ CDK17 ▸
VDAC2 ▸ PSENEN ▸ GPX3 ▸ CDK18 ▸ GSTT1 ▸ IFI44 ▸ TNFRSF8 ▸
IRF8 ▸ HRK ▸ SIVA1 ▸ NPPA ▸ MED6 ▸ HDAC6 ▸ RAC3 ▸
NR0B1 ▸ CCK ▸ GYS2 ▸ ATF2 ▸ PNPLA2 ▸ SAA1 ▸ RAD50 ▸
SATB1 ▸ GRP ▸ EMP2 ▸ RAC2 ▸ RAD21 ▸ MTA1 ▸ PGF ▸
MTA2 ▸ CCR9 ▸ CFL1 ▸ PLK1 ▸ ADM ▸ CCR5 ▸ APIP ▸
CIB1 ▸ TNFSF12 ▸ KLF4 ▸ MLYCD ▸ NTN1 ▸ FAF1 ▸ LRRC59 ▸
EML2 ▸ CXCL13 ▸ PRG2 ▸ CTRL ▸ BCAP31 ▸ STC1 ▸ HTRA1 ▸
CDK20 ▸ PSMB9 ▸ PAN2 ▸ CDK6 ▸ CFTR ▸ RARA ▸ TMED7 ▸
DAPK2 ▸ SEPT4 ▸ SREBF2 ▸ MED14 ▸ ANG ▸ ACSM3 ▸ WNT3A ▸
IFIH1 ▸ MST1R ▸ TFAP2A ▸ NANOS2 ▸ CCR8 ▸ CCR2 ▸ AFP ▸
CCR4 ▸ GNA11 ▸ CDK13 ▸ PC ▸ RUNX3 ▸ GNRH1 ▸ MED13 ▸
TAC3 ▸ SERPINF1 ▸ EMP1 ▸ SUB1 ▸ MED7 ▸ CRYAB ▸ VIP ▸
ABCD1 ▸ ING1 ▸ IRS1 ▸ CDK10 ▸ BNIP3 ▸ PARG ▸ HTRA4 ▸
PLD4 ▸ MED15 ▸ MED1 ▸ NTF4 ▸ CDK12 ▸ CD8B ▸ DAXX ▸
KMT2A ▸ ATG3 ▸ CDK9 ▸ ETS2 ▸ PIN1 ▸ PLD6 ▸ ATF5 ▸
NLRP7 ▸ PRG3 ▸ BLM ▸ CPA1 ▸ HMGCR ▸ SERPINB9 ▸ IRF7 ▸
ADH5 ▸ CCNH ▸ IGFBP3 ▸ DHCR24 ▸ CCR1 ▸ PPT1 ▸ CCL19 ▸
HTRA3 ▸ MED21 ▸ TSC22D3 ▸ HRD ▸ CPOX ▸ TET1 ▸ MTA3 ▸
HCLS1 ▸ TRAF5 ▸ LRP1 ▸ ID3 ▸ ACIN1 ▸ SRC ▸ CDK7 ▸
PRKAB2 ▸ PTPN11 ▸ ZGLP1 ▸ CCR3 ▸ DNAJC5 ▸ STSP1 ▸ TRAF7 ▸
VDAC3 ▸ EIF4G1 ▸ PLD3 ▸ NAB2 ▸ ANP32A ▸ CAPNS1 ▸ CDK3 ▸
SMAD4 ▸ FAM168B ▸ MED12 ▸ ATM ▸ IRF9 ▸ CTNND1 ▸ LGALS1 ▸
GPX1 ▸ MME ▸ STX2 ▸ TET2 ▸ GPI ▸ MAP2 ▸ TRA ▸
C22orf29 ▸ PPP1R3A ▸ TAC4 ▸ CALML3 ▸ NTF3 ▸ THBS1 ▸ PLIN4 ▸
ATN1 ▸ FIS1 ▸ PIAS1 ▸ COL5A2 ▸ PTPN6 ▸ ACTA2 ▸ ARHGDIA ▸
TRIM28 ▸ EP300 ▸ UBB ▸ NOL3 ▸ COL11A2 ▸ MAPT ▸ CUL3 ▸
NEFH ▸ USP54 ▸ RNF135 ▸ CD3G ▸ KRR1 ▸ OTUD7B ▸ KHDRBS1 ▸
CD3E ▸ STK24 ▸ TNFSF14 ▸ ACTG2 ▸ TICAM2 ▸ IFT57 ▸ DEDD2 ▸
PLA2G4B ▸ RALGDS ▸ KARS ▸ COL1A1 ▸ COL4A5 ▸ MAP3K14 ▸ TNFAIP3 ▸
PIDD1 ▸ TOPORS ▸ COL4A4 ▸ COPS6 ▸ TUBA1C ▸ PARK2 ▸ NUCB1 ▸
ITGA2 ▸ PDIA6 ▸ CRADD ▸ COL6A3 ▸ RPS27L ▸ COL7A1 ▸ CLTC ▸
CHD3 ▸ CDK11B ▸ PICALM ▸ RALBP1 ▸ SORBS1 ▸ ATAD3A ▸ UBE2L3 ▸
ITGB3 ▸ NR1H4 ▸ RAB10 ▸ NUCB2 ▸ IRS4 ▸ EZR ▸ EDA2R ▸
HIST1H4A ▸ RPS27 ▸ MAP1LC3A ▸ SPARC ▸ TFCP2 ▸ TUBB ▸ PARK7 ▸
CASP8AP2 ▸ COL6A2 ▸ ATG4D ▸ TUBA1A ▸ UBR5 ▸ MSN ▸ COL1A2 ▸
ITGAV ▸ COL4A3 ▸ CDK11A ▸ RNF34 ▸ EIF3S10 ▸ TRIM25 ▸ YES1 ▸
CD247 ▸ NCL ▸ HNRNPH2 ▸ IL1R1 ▸ PTPN13 ▸ GRIA1 ▸ MALT1 ▸
IL1R2 ▸ AR ▸ COL3A1 ▸ EIF4A1 ▸ CD3D ▸ COL5A1 ▸ COL4A6 ▸
SYF2 ▸ CD14 ▸ PLEC ▸ CLIP3 ▸ MAP4K4 ▸ COL4A1 ▸ COL6A1 ▸
UBC ▸ BFAR ▸ USP2 ▸ MAP1LC3B ▸ TNFRSF25 ▸ PYCARD ▸ COL2A1 ▸
ITGB1 ▸ MYO9A ▸ PCYT1A ▸ UBE2D1 ▸ COL11A1 ▸ BNIP3L ▸ DDX28 ▸
LY96 ▸ SQSTM1 ▸ IQGAP1 ▸ PRKCI ▸ DNAJC7 ▸
Data information
Please see the Gene Interactions Track Manual.