Gene interactions and pathways from curated databases and text-mining

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CD4 — STAT3

Text-mined interactions from Literome

Kitamura et al., Immunity 2005 : Thus, IL-6-STAT3 mediated increase of cathepsin S activity reduces the MHCII alphabeta dimer, Ii, and H2-DM levels in DCs, and suppresses CD4 ( + ) T cell mediated immune responses
Wang et al., Cell Immunol 2007 : The role of STAT3 in antigen-IgG inducing regulatory CD4 ( + ) Foxp3 ( + ) T cells
Rafei et al., J Immunol 2009 (Encephalomyelitis, Autoimmune, Experimental) : In an effort to decipher MSC mode of action, we found that MSC conditioned medium inhibits EAE derived CD4 T cell activation by suppressing STAT3 phosphorylation via MSC derived CCL2
Alam et al., Proc Natl Acad Sci U S A 2010 (Hepatitis, Animal) : Notch mediated stimulation of CD4 ( + ) T cells increased the production of IL-22 even in the absence of STAT3
Manuel et al., Cancer Res 2011 (Melanoma, Experimental) : In vaccinated mice, silencing STAT3 increased the proliferation and granzyme B levels of intratumoral CD4 ( + ) and CD8 ( + ) T cells