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MAPK3 — TIMP1
Text-mined interactions from Literome
Domeij et al., J Periodontal Res 2004
:
Tyrosine kinase inhibitor herbimycin A reduced MMP-1 production induced by PMA, whereas the p38
MAPK-inhibitor SB 203580 synergistically
increased the stimulatory effect of PMA on both MMP-1 and
TIMP-1 production
Yoshida et al., Biochem Biophys Res Commun 2004
(Adenocarcinoma...) :
Inhibition of
ERK 1/2 phosphorylation ( U0126 )
prevented the increases in growth and
TIMP-1 expression
Studer et al., J Orthop Res 2005
:
In contrast, COX2 inhibition did not modulate TIMP-1 production while p38
MAPK inhibitors
potentiated TGF-beta stimulated production of
TIMP-1 in IL-1 activated cartilage ... p38
MAPK inhibition blunts TGF-beta stimulation of proteoglycan synthesis, but
increases TIMP-1 synthesis
Morquette et al., Arthritis Rheum 2006
(Osteoarthritis) :
In isolated OA chondrocytes, HNE inhibited the expression of CII and
tissue inhibitor of metalloproteinases 1 and
induced MMP-13 mainly through activation of p38
MAPK
Nee et al., Nephron. Experimental nephrology 2007
:
Activation of the
ERK 1/2 MAPK
mediated both the upregulation of MMP-9 and the inhibition of
TIMP-1 following TNF-alpha treatment
Bigelow et al., Breast Cancer Res Treat 2009
(Breast Neoplasms) :
However, overexpression of
TIMP-1 in MDA-MB-231 cells
resulted in inhibition of cell invasion and enhanced phosphorylation of p38
MAPK and AKT in vitro
Li et al., Biol Reprod 2010
(Abortion, Spontaneous...) :
Moreover, U0126, or anti-integrinbeta1 neutralizing antibody, reverses the decreased
TIMP1 expression and the increased invasiveness of trophoblast cells, and the antibody also
inhibits the
MAPK3/1 phosphorylation induced by CD82 silence
Polimeni et al., PloS one 2013
(MAP Kinase Signaling System) :
p38
MAPK and NF-?B inhibitors
blocked all nHZ effects on
TIMP-1 and pro-inflammatory molecules
Yamashita et al., FEBS Lett 1996
(Osteosarcoma) :
We also found that either
TIMP stimulated an increase in
mitogen activated protein ( MAP ) kinase activity, suggesting that MAP kinase plays a role in TIMP dependent growth signaling