Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
CASP8
→
Complex of COL1A1-ITGA2-ITGB1
(decreases, COL1A1/ITGA2/ITGB1 Activity)
Gendron et al., J Biol Chem 2003* Evidence: In experiments done in Jurkat T cells and activated peripheral blood T lymphocytes, engagement of alpha2beta1 integrin with collagen type I (Coll I) was found to significantly reduce Fas-induced apoptosis and caspase-8 activation