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MMP9 — RHOA
Text-mined interactions from Literome
Abécassis et al., Exp Cell Res 2003
:
RhoA induces
MMP-9 expression at CD44 lamellipodial focal complexes and promotes HMEC-1 cell invasion
Chan et al., Cardiovasc Ther 2012
(Diabetes Mellitus) :
Under high glucose conditions, simvastatin dose-dependently inhibited VSMC migration, decreased PI3K/Akt pathway activity, reduced c-Raf and Ras expression, increased RhoB but not
RhoA , Rac1, and Cdc2 expression, dose-dependently
inhibited MMP-2, but not
MMP-9 , activity, and dose-dependently inhibited NF-?B activity
Serratì et al., Arthritis Rheum 2013
(Scleroderma, Systemic) :
Motility increase required Rac1 activation and
RhoA inhibition and was
inhibited by an
MMP inhibitor