Gene interactions and pathways from curated databases and text-mining

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MMP9 — RHOA

Text-mined interactions from Literome

Abécassis et al., Exp Cell Res 2003 : RhoA induces MMP-9 expression at CD44 lamellipodial focal complexes and promotes HMEC-1 cell invasion
Chan et al., Cardiovasc Ther 2012 (Diabetes Mellitus) : Under high glucose conditions, simvastatin dose-dependently inhibited VSMC migration, decreased PI3K/Akt pathway activity, reduced c-Raf and Ras expression, increased RhoB but not RhoA , Rac1, and Cdc2 expression, dose-dependently inhibited MMP-2, but not MMP-9 , activity, and dose-dependently inhibited NF-?B activity
Serratì et al., Arthritis Rheum 2013 (Scleroderma, Systemic) : Motility increase required Rac1 activation and RhoA inhibition and was inhibited by an MMP inhibitor