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APOB — HMOX1

Text-mined interactions from Literome

Siow et al., Cardiovasc Res 1999 (Arteriosclerosis) : This review examines the evidence that oxidized low density lipoproteins (LDL) , hypoxia and pro-inflammatory cytokines induce HO-1 expression and activity in vascular endothelial and smooth muscle cells, and evaluates the anti-atherogenic potential of the heme oxygenase signalling pathway
Ishii et al., Circ Res 2004 (Arteriosclerosis) : In murine aortic smooth muscle cells, expressing negligible levels of CD36, both moderately and highly oxidized LDL caused only limited Nrf2 translocation and negligible increases in A170, HO-1 , and Prx I expression
Anwar et al., Free Radic Biol Med 2005 (Arteriosclerosis...) : Oxidized low-density lipoproteins (LDL) play a central role in atherogenesis and induce expression of the antioxidant stress protein heme oxygenase 1 (HO-1) ... These findings demonstrate for the first time that activation of PKC, p38 ( MAPK ), JNK, ERK1/2, and Nrf2 by oxidized LDL in human SMC leads to HO-1 induction, constituting an adaptive response against oxidative injury that can be ameliorated by vitamin C
Nagy et al., Cell Mol Biol Incl Cyto Enzymol 2005 : Oxidation of hemoglobin by lipid hydroperoxide associated with low-density lipoprotein (LDL) and increased cytotoxic effect by LDL oxidation in heme oxygenase-1 (HO-1) deficiency
Muellner et al., Biochem J 2009 : The ability of LOOH enriched LDL to induce HO-1 ( haem oxygenase 1 ) in endothelial cells was abolished by H2S pretreatment
Ishikawa et al., J Clin Invest 1997 : Heme oxygenase-1 (HO-1) , the inducible isoform of HO, was highly induced by mildly oxidized LDL , and augmented induction was observed with hemin pretreatment ... These results suggest that HO-1 induced by mildly oxidized LDL may protect against the induction of inflammatory responses in artery wall cells through the production of the antioxidants biliverdin and bilirubin
Agarwal et al., J Am Soc Nephrol 1998 : To identify the constituents and molecular mechanisms of oxidized LDL mediated HO-1 induction, human renal epithelial cells and aortic endothelial cells were exposed to LAox and lyso-PC