UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

ETV6 — STAT3

Pathways - manually collected, often from reviews:

OpenBEL Selventa BEL large corpus: STAT3 → ETV6 (decreases, ETV6 Activity) Schick et al., J Biol Chem 2004 *
Evidence: We found that TEL (ETV6), a novel Stat3 target identified in this study, is a negative regulator of Stat3 activity

Text-mined interactions from Literome

Ho et al., Blood 1999 : TEL-Jak2 activation resulted in the constitutive tyrosine phosphorylation of Stat1, Stat3 , and Stat5 as determined by detection of phosphorylation using activation-specific antibodies and by binding of each protein to a preferential GAS sequence in electrophoretic mobility shift assays
Spiekermann et al., Exp Hematol 2002 (Cell Transformation, Neoplastic...) : Stable transfection of BA/F3 cells with TEL-JAK2, TEL-ABL, and BCR-ABL resulted in IL-3 independent growth and strong activation of STAT3 and STAT5 by TEL-JAK2 and TEL-ABL, but not by BCR-ABL
Schick et al., J Biol Chem 2004 : Small interfering RNA mediated inhibition of TEL expression resulted in increased Stat3 dependent transcriptional activity and stronger Stat3 antiproliferative activity ... Confirming these results, overexpression of TEL repressed Stat3 transcriptional activity ... Intriguingly, Stat3 repression did not require TEL DNA binding and appeared to proceed via recruitment of TEL to Stat3