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PRKAR2A — ZGLP1

Text-mined interactions from Literome

Reimer et al., Endocrinology 2001 : Activators of PKA and PKC were able to increase GLP-1 secretion in NCI-H716 cells
Ni et al., J Biol Chem 2003 : Although proglucagon transcription and GLP-1 synthesis were shown to be activated by forskolin and other protein kinase A (PKA) activators, deleting or mutating the cAMP-response element ( CRE ) only moderately attenuates the proglucagon gene promoter in response to PKA activation
Ong et al., Br J Pharmacol 2009 : A role for intracellular cAMP/PKA in enhancing GLP-1 release in response to overexpression of D556A-PDE4D5 mutant was demonstrated by the finding that the PKA inhibitor H89 reduced both basal and glucose induced GLP-1 release by 37 % and 39 %, respectively, from C1 GLUTag cells
Dong et al., Am J Physiol Endocrinol Metab 2013 : In cultured endothelial cells, GLP-1 acutely increased PKA activity and stimulated endothelial NO synthase phosphorylation at Ser ( 1177 ) and NO production
Luo et al., Int J Biochem Cell Biol 2013 (Second Messenger Systems) : It is of note that GLP-1 preferentially increased the expression and activity of PKA , whereas had no effects on Epac2 at high glucose
Moberly et al., Basic Res Cardiol 2013 (Diabetes Mellitus, Type 2...) : No evidence for GLP-1 mediated activation of cAMP/PKA or AMPK signaling in lean or obese hearts was observed