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IL12A — IL23A

Text-mined interactions from Literome

Puccetti et al., Crit Rev Immunol 2002 : However, although both cytokines enhance the Th1 costimulatory functions of APCs, and IL-23 does induce IL-12 from APCs, their effects, which in part overlap, can be differentiated from one another
Ireland et al., Viral Immunol 2005 (Encephalitis, Viral...) : Furthermore, these data indicate that IL-23 is not acting redundantly in the absence of IL-12 during VSV induced encephalitis
Shan et al., Cell Mol Immunol 2006 (Carcinoma...) : IL-23 also promoted the production of Th1 cytokines such as IFN-gamma, IL-12 and TNF-alpha
Hao et al., Cancer Immunol Immunother 2006 (Neoplasms) : IL-23 can enhance the proliferation of memory T cells and the production of IFN-gamma, IL-12 and TNF-alpha from activated T cells
Nakae et al., J Leukoc Biol 2007 : We found that IL-23 or IL-17 can suppress Th1 cell differentiation in the presence of exogenous IL-12 in vitro
Gerosa et al., J Exp Med 2008 : DC priming with interferon (IFN) gamma strongly increased IL-12 production, but was not required for IL-23 production and inhibited IL-23 production induced by beta-glucan
Kim et al., J Immunol 2008 (Neoplasms, Experimental) : IL-12p40 is a natural antagonist which inhibits IL-12- and IL-23 mediated biological activity by blocking the binding of IL-12/23 to their receptors
Schulz et al., J Immunol 2008 (Necrosis...) : To analyze the role of IL-23 in the absence of IL-12 , low doses of S. Enteritidis were administered to p35 ( -/- ) mice ( lacking IL-12 ), p35/19 ( -/- ) mice ( lacking IL-12 and IL-23 ), p35/40 ( -/- ) mice ( lacking IL-12, IL-23, and homodimeric IL-12p40 ), or p35/IL-17A ( -/- ) mice ( lacking IL-12 and IL-17A )
Lyakh et al., Immunol Rev 2008 : Mycobacterium tuberculosis and yeast zymosan induce IL-23 , but in the absence of other stimuli, no IL-12 is induced in human dendritic cells (DCs)
Cooper et al., Immunol Rev 2008 (Tuberculosis) : IL-23 can induce IFN-gamma responses in the lung if IL-12 is not present, but its major role is in supporting the IL-17 response within the lung
Stewart et al., Cancer Cell 2009 (Neoplasms) : In this issue of Cancer Cell, Kortylewski et al. show that in the tumor microenvironment, STAT3 enhances the expression of the protumor cytokine IL-23 in macrophages but inhibits the antitumor cytokine IL-12 in dendritic cells
Uemura et al., J Immunol 2009 : This study demonstrates that the activation of human iNKT cells by their specific ligand alpha-galactosylceramide enhances IL-12p70 while inhibiting the IL-23 production by monocyte derived dendritic cells, and in turn down regulating the IL-17 production by memory CD4 ( + ) Th cells
Rovedatti et al., Gut 2009 (Colitis, Ulcerative...) : IL23 and IL1beta plus IL6 had no effect on IBD LPMC production of IL17 ; however, IL12 markedly increased IFNgamma production and decreased IL17 production
Haas et al., Eur J Immunol 2009 : IL-12 and IL-18 induced IFN-gamma and IL-23 induced IL-17A production by NK1.1+ or CCR6+ gammadelta T cells, respectively
van de Wetering et al., PloS one 2009 (Salmonella Infections) : Both IFN-gamma and GM-CSF enhanced IL-23 production by monocytes in response to TLR agonists, as well as induced IL-12 production ... The IL-23 induced cytokines allow for the subsequent production of IL-12 and amplify the IFN-gamma production in the type-1 cytokine pathway
Zhang et al., Clin Neurol Neurosurg 2010 (Autoimmune Diseases...) : IFNbeta inhibited IL-1beta, IL-23 and transforming growth factor ( TGF ) -beta ( which induce Th17 cell differentiation ), and induced IL-27, IL-12p35 and IL-10 ( which suppress it ) in dendritic cells (DCs) and B-cells
Donini et al., Prostate 2012 (Prostatic Neoplasms) : LNCaP enhance IL-1ß, IL-23 , IL-6, and TNF-a secretion by decreasing glucan dependent NADPH oxidase activity, whereas glucan increases IL-12 production through NADPH oxidase unrelated mechanisms
Reay et al., Cancer Gene Ther 2012 (Fibrosarcoma) : These results demonstrate that although significant antitumor effects are achieved by intratumoral injection of adenovirus expressing either scIL-23 or IL-12 alone and that IL-23 requires endogenous IL-12 for maximum antitumor benefit, the combined use of these cytokines provides no additive or synergistic effect
McBerry et al., J Immunol 2012 (Disease Models, Animal...) : p38 MAPK activation and IL-12p70 production was more robust from TFF2 ( -/- ) CD8+ DC compared with WT CD8+ DC and treatment of WT DC with rTFF2 suppressed TLR induced IL-12/23p40 production
Wang et al., J Virol 2013 (Hepatitis C, Chronic) : We found that Tim-3 and IL-23p19 are highly expressed and that IL-12p35 is inhibited in human CD14 ( + ) monocytes, while IL-17 expression is upregulated in CD4 ( + ) T cells, in chronically HCV infected individuals compared to healthy subjects
Carrión et al., Neuroimmunomodulation 2013 : VIP decreased IL-12p35 mRNA upregulation by poly ( I:C ) and IL-23p19 transcripts in LPS treated FLS