◀ Back to HIF1A

HIF1A — IL1B

Text-mined interactions from Literome

Hellwig-Bürgel et al., Blood 1999 (Anoxia...) : Only IL-1beta increased HIF-1alpha protein levels
Haddad et al., Eur Cytokine Netw 2002 : Furthermore, evidence that reactive oxygen species ( ROS ) signaling mediates interleukin (IL)-1 beta dependent regulation of HIF-1 alpha has yet to be ascertained in alveolar epithelial cells ... Recombinant human IL-1 beta induced , in a time dependent manner, the nuclear translocation of HIF-1 alpha , an effect associated with up-regulating the activity of this transcription factor under normoxic conditions ... The antioxidants, dimethyl sulfoxide ( DMSO ) and 1,3-dimethyl-2-thiourea ( DMTU ), purported to be prototypical scavengers of H2O2 and *OH, attenuated, in a dose dependent manner, IL-1 beta induced HIF-1 alpha nuclear translocation and activation ... Inhibition of the mitochondrion complex I nicotinamide adenine dinucleotide phosphate dependent oxidase by diphenylene iodonium ( DPI ), which blocks the conversion of ubiquinone -- > ubiquinol, abrogated IL-1 beta dependent nuclear translocation and activation of HIF-1 alpha ... Similarly, interrupting the respiratory chain with potassium cyanide reversed the excitatory effect of IL-1 beta on HIF-1 alpha nuclear translocation and activation
Jung et al., FASEB J 2003 (Inflammation...) : IL-1beta mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis
Hellwig-Bürgel et al., Cell Physiol Biochem 2005 : The study shows that PI3K but not MAPKK-1 inhibition resulted in the loss of hypoxic and IL-1beta induced HIF-1alpha accumulation, whereas VEGF synthesis was reduced by either intervention
Zhang et al., J Neuroimmunol 2006 : Inhibition of HIF-1alpha degradation by proteasome inhibitor, MG-132, potentiated hypoxia induced IL-1beta release from human astrocytes, and this response was blocked in the presence of CdCl2. Mouse astrocytes with Hif1alpha+/- genotype demonstrated attenuated up-regulation of both HIF-1alpha and IL-1beta by hypoxia and CoCl2
Kimura et al., Br J Pharmacol 2006 (Burns) : 3. In human keratinocyte cultures ( HaCaT cells ), ginsenoside Rb1 ( 100 fg ml(-1) to 1 ng ml(-1) ) enhanced VEGF production induced by IL-1beta and expression of hypoxia-inducible factor (HIF)-1alpha
Argaw et al., J Immunol 2006 (Anoxia...) : Suggesting functional significance, we found that expression of IL-1beta in the brain induced astrocytic expression of HIF-1alpha , VEGF-A, and BBB permeability ... In addition, we confirmed VEGF-A to be a potent inducer of BBB permeability and angiogenesis, and demonstrated the importance of IL-1beta induced HIF-1alpha in its regulation
Mojsilovic-Petrovic et al., Journal of neuroinflammation 2007 : We have recently shown that hypoxia induced expression of IL-1beta in astrocytes is mediated by HIF-1alpha
Stasinopoulos et al., Cancer Biol Ther 2009 (Anoxia...) : These data suggest that the profound effects of COX-2 silencing on inhibiting invasion, tumor growth and metastasis from MDA-MB-231 cells are dependent on the induction of IL-1beta dependent COX-2 and HIF-1alpha but are independent of hypoxia
Zhu et al., Osteoarthritis Cartilage 2009 : Additionally, IL-1beta stimulated both HIF-1alpha and PAI-1 in articular chondrocytes, and the IL-1beta mediated induction of PAI-1 was inhibited partly by HIF-1alpha silencing