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CHUK — PRKCA

Pathways - manually collected, often from reviews:

• NCI Pathway Database TCR signaling in naïve CD8+ T cells: PKC alpha (PRKCA) → IKK complex complex (CHUK-IKBKB-IKBKG) (modification, activates)
  Dreikhausen et al., Int Immunol 2003
  Evidence: mutant phenotype
• NCI Pathway Database Canonical NF-kappaB pathway: IKK complex/PKC alpha complex (CHUK-IKBKB-IKBKG-PRKCA) → PKC alpha (PRKCA) (modification, collaborate) Zhong et al., Mol Cell 1998
  Evidence: physical interaction
• NCI Pathway Database Canonical NF-kappaB pathway: IKK complex/PKC alpha complex (CHUK-IKBKB-IKBKG-PRKCA) → IKK complex complex (CHUK-IKBKB-IKBKG) (modification, collaborate)
  Zhong et al., Mol Cell 1998
  Evidence: physical interaction
• NCI Pathway Database Canonical NF-kappaB pathway: PKC alpha (PRKCA) → IKK complex complex (CHUK-IKBKB-IKBKG) (modification, collaborate)
  Zhong et al., Mol Cell 1998
  Evidence: physical interaction
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: PKC alpha (PRKCA) → IKK complex complex (CHUK-IKBKB-IKBKG) (modification, activates)
  Dreikhausen et al., Int Immunol 2003
  Evidence: mutant phenotype
• NCI Pathway Database Canonical NF-kappaB pathway: IKK complex/ELKS complex (CHUK-IKBKB-IKBKG-ERC1) → IKK complex/PKC alpha complex (CHUK-IKBKB-IKBKG-PRKCA) (modification, activates)
  Sakurai et al., J Biol Chem 1999, Ducut Sigala et al., Science 2004, Brockman et al., Mol Cell Biol 1995, Brown et al., Science 1995, Zhong et al., Cell 1997, Zhong et al., Mol Cell 1998
  Evidence: assay, physical interaction
• NCI Pathway Database Canonical NF-kappaB pathway: IKK complex/PKC alpha complex (CHUK-IKBKB-IKBKG-PRKCA) → NF kappa B1 p50/RelA/I kappa B alpha complex (NFKB1-NFKBIA-RELA) (modification, activates)
  Sakurai et al., J Biol Chem 1999, Ducut Sigala et al., Science 2004, Brockman et al., Mol Cell Biol 1995, Brown et al., Science 1995, Zhong et al., Cell 1997, Zhong et al., Mol Cell 1998
  Evidence: assay, physical interaction
• NCI Pathway Database Canonical NF-kappaB pathway: IKK complex/PKC alpha complex (CHUK-IKBKB-IKBKG-PRKCA) → IKK complex complex (CHUK-IKBKB-IKBKG) (modification, activates)
  Sakurai et al., J Biol Chem 1999, Ducut Sigala et al., Science 2004, Brockman et al., Mol Cell Biol 1995, Brown et al., Science 1995, Zhong et al., Cell 1997, Zhong et al., Mol Cell 1998
  Evidence: assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CHUK — PRKCA (direct interaction, pull down) Lallena et al., Mol Cell Biol 1999
• IRef Biogrid Interaction: CHUK — PRKCA (physical association, affinity chromatography technology) Lallena et al., Mol Cell Biol 1999

Text-mined interactions from Literome

Vertegaal et al., Cell Signal 2000 : Activation of the IKK complex in response to TPA is mediated by PKC-alpha , since both the PKC inhibitor GF109203 and a catalytically inactive PKC-alpha mutant inhibit activation of endogenous IKK by TPA, but not by tumor necrosis factor-alpha (TNF-alpha)
Trushin et al., Mol Cell Biol 2003 : Herein, we demonstrate using genetic analysis, pharmacological inhibition, and RNA interference ( RNAi ) that the conventional protein kinase C ( PKC ) isoform PKCalpha , but not PKCbeta1, is required for the activation of the IKK complex following T-cell activation triggered by CD3/CD28 cross linking