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APP — LRP10
Text-mined interactions from Literome
Hyman et al., Arch Neurol 2000
(Alzheimer Disease) :
In this review, we highlight data that support a role for LRP in A beta metabolism and hypothesize that
LRP therefore
plays a critical role in
Alzheimer disease
Pietrzik et al., J Neurosci 2004
:
We have shown previously that
LRP mediates beta-amyloid precursor protein (APP) processing and
affects amyloid beta-protein and APP secretion and
APP-c-terminal fragment generation ... Indeed, FE65 was only able to increase
APP secretion in the
presence of
LRP
Brodeur et al., Molecular neurodegeneration 2012
(Alzheimer Disease) :
Increased expression of
LRP10 in human neuroblastoma SH-SY5Y cells
induces the accumulation of mature
APP in the Golgi and reduces its presence at the cell surface and its processing into Aß, while knockdown of LRP10 expression increases Aß production
Postuma et al., FEBS Lett 1998
(Alzheimer Disease) :
As LRP may regulate neurite outgrowth, we examined whether the effects of
APP are
mediated by
LRP ... Thus the effect of substrate bound
APP on neurite outgrowth is not
mediated by
LRP