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AKT1 — ZGLP1

Text-mined interactions from Literome

Trümper et al., Ann N Y Acad Sci 2000 : Insulin, IGF-1, and GLP-1 induced distinctive time dependent, dose dependent, and glucose dependent phosphorylation of PKB/Akt ... Insulin, IGF-1, and GLP-1 induced distinctive time dependent, dose dependent, and glucose dependent phosphorylation of PKB/Akt
Buteau et al., Diabetes 2001 : GLP-1 increased extracellular signal related kinase 1/2, p38 mitogen activated protein kinase ( MAPK ), and protein kinase B activities nonadditively with glucose in pancreatic beta ( INS 832/13 ) cells
Redondo et al., Mol Cell Endocrinol 2003 : GLP-1 , like insulin, activates PI3K/PKB , p70s6k, p44 and p42 MAP-kinase
Acitores et al., J Endocrinol 2004 : We first explored the effect of GLP-1 , compared with that of insulin, on the activation of PI3K, PKB , p70s6 kinase (p70s6k) and p44/42 mitogen activated protein kinases ( MAPKs ) and the action of specific inhibitors of these kinases on the insulin- and GLP-1 induced increment in glycogen synthase a activity ... The study showed that GLP-1 , like insulin, activated PI3K/PKB , p70s6k and p44/42
González et al., Regul Pept 2005 : In conclusion, GLP-1 , like insulin, stimulates glucose uptake, and this involves activation of PI3K/PKB , p44/42 MAPKs, partially p70s6k, and possibly PKC ; Ex-4 and Ex-9 both have GLP-1-like effect upon glucose transport, in which both share with GLP-1 an activation of PI3K/PKB -- partially in the case of Ex-4 -- and p44/42 MAPKs but not p70s6k
Sancho et al., J Mol Endocrinol 2005 (Diabetes Mellitus, Experimental) : In cells from STZ-rats the magnitude of the above parameters was, in general, comparable to that in normal animals, with some exceptions : basal PI3K activity and lipogenesis were higher, GLP-1 , Ex-4 and Ex-9 failed to modify basal lipogenesis but increased PKB activity, insulin failed to affect the activity of MAPKs and the insulin induced glucose uptake was impaired
Huisamen et al., Cardiovasc J S Afr 2008 (Disease Models, Animal...) : GLP-1 could not directly activate protein kinase B ( also called Akt ) or the extracellular regulated kinases Erk1/2 in hearts or cardiocytes under normoxic conditions, but phosphorylation of the AMP activated kinase (AMPK) on Thr ( 172 ) was enhanced
Peyot et al., PloS one 2009 : GLP-1 activated PKB without changing glucose usage and oxidation, fatty acid oxidation, lipolysis or esterification into various lipids in rat islets
Ban et al., Endocrinology 2010 (Reperfusion Injury) : Both GLP-1 ( 9-36 ) amide and exendin-4 increased levels of cAMP and phosphorylation of ERK1/2 and the phosphoinositide 3-kinase target protein kinase B/Akt ... Both GLP-1 ( 9-36 ) amide and exendin-4 increased levels of cAMP and phosphorylation of ERK1/2 and the phosphoinositide 3-kinase target protein kinase B/Akt
Wang et al., Metabolism 2011 : The effects of GLP-1 and/or candesartan on glucolipotoxicity induced apoptosis and the phosphorylation of insulin receptor substrate-2 (IRS-2), protein kinase B (PKB) , and forkhead box O1 (FoxO1) were evaluated by using MIN6 cells and isolated mouse pancreatic islets
Kimura et al., Neuroendocrinology 2013 (Brain Diseases, Metabolic...) : Moreover, these agents reduced GLP-1 induced phosphorylation of Akt