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Morse et al., Mol Immunol 2009
:
However in lymphocytes, TRB3 did not reduce the phosphorylation of AKT , and WY14,643 treatment was associated with enhanced activation of AKT
Cunha et al., Diabetes 2012
:
PUMA expression is also PERK/ATF3 dependent, through tribbles 3 (TRB3) regulated AKT inhibition and FoxO3a activation
Li et al., Am J Physiol Endocrinol Metab 2012
(Insulin Resistance...) :
Moreover, decreased acetylation of FoxO1 was accompanied by decreased expression of pseudokinase tribble 3 (TRB3) and reduced the association between TRB3 and Akt , which enhanced insulin sensitivity and improved glucose metabolism