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AKT1 — SOX9

Text-mined interactions from Literome

Cheng et al., J Cell Physiol 2009 : PI3K/AKT regulates aggrecan gene expression by modulating Sox9 expression and activity in nucleus pulposus cells of the intervertebral disc ... We observed that PI3K maintained Sox9 gene expression and activity : inhibition of PI3K/AKT resulted in decreased Sox9 expression, lowered promoter activity, and mediated a reduction in Sox9 transcriptional activity
Yin et al., J Biol Chem 2009 : CA Akt also promoted type II collagen and Sox9 expression, whereas tBHP treatment and CA MEK inhibited aggrecan, collagen II, and Sox9 mRNA expression