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AKT1 — SNAI2

Text-mined interactions from Literome

Subramaniam et al., Arch Pathol Lab Med 2011 (Sarcoma, Synovial) : In monophasic fibrous tumors, increased expression of Snail ( 17 of 27 ; 63 % ), Slug ( 18 of 27 ; 67 % ), and dysadherin ( 14 of 27 ; 52 % ) and activation of Wnt ( nucleocytoplasmic ß-catenin accumulation in 63 % ; n = 27 ; and positive expression of GSK3 and pGSK3 in 24 of 27 [ 89 % ] and 21 of 27 [ 78 % ], respectively ) and PI3K/Akt ( Akt : 22 of 27 [ 81 % ] ; pAkt : 25 of 27 [ 93 % ] ; and PI3K : 20 of 27 [ 74 % ] ) signaling correlated significantly with inactivated E-cadherin expression ( 1 of 27 ; 4 % )
Cheng et al., J Clin Endocrinol Metab 2012 : Moreover, the inhibition of EGF induced ERK1/2, p38, and Akt activation by pharmacological inhibitors attenuated EGF induced Slug expression and the down-regulation of E-cadherin, as well as subsequent cell invasion
Fenouille et al., PloS one 2012 (Cell Transformation, Neoplastic...) : These findings reveal that autocrine SPARC maintains heightened SLUG expression in melanoma cells and indicate that SPARC may promote EMT associated tumor invasion by supporting AKT dependent upregulation of SLUG