◀ Back to AKT1
AKT1 — NFKBIA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Saleem et al., Oncogene 2004
(Edema...) :
We found that Lupeol treatment to mouse skin resulted in the inhibition of TPA induced ( i )
activation of PI3K, ( ii ) phosphorylation of
Akt at Thr ( 308 ), ( iii ) activation of NF-kappaB and IKKalpha, and ( iv ) degradation and phosphorylation of
IkappaBalpha
Yang et al., J Biol Chem 2005
:
Thus, IFN induces NF-kappaB activation to mediate IFN dependent cell survival signals through a `` canonical '' pathway of
IkappaB alpha proteolysis
mediated by
PI3K/Akt and a `` noncanonical '' pathway of p100 processing mediated by NIK/TRAF
Yasui et al., Cancer Res 2005
(Multiple Myeloma) :
Finally, it down-regulates interleukin-6 induced phosphorylation of
Akt , signal transducers and activators of transcription 3, and p42/44 mitogen activated protein kinase ; insulin-like growth factor-I triggered Akt phosphorylation ; and tumor necrosis factor alpha
induced IkappaBalpha and nuclear factor-kappaB p65 phosphorylation
Ouyang et al., Carcinogenesis 2006
(Skin Neoplasms) :
Furthermore, inhibition of
PI-3K/Akt by overexpression of Deltap85 or DN-Akt
blocked arsenite induced IKK phosphorylation,
IkappaBalpha degradation and cyclin D1 expression, indicating that IKK/NFkappaB is the downstream transducer of arsenite triggered PI-3K/Akt cascade
Tong et al., Respir Res 2006
:
In addition, HIMF strongly induced Akt phosphorylation, and suppression of
Akt activation by specific inhibitors and dominant negative mutants for PI-3K, and IKK or
IkappaBalpha blocked HIMF induced NF-kappaB activation and attenuated HIMF induced VEGF production
Tsai et al., Int Immunopharmacol 2007
:
YC-1, in a cGMP independent manner,
inhibited lipopolysaccharide induced
Akt activation,
IkappaBalpha degradation and NF-kappaB translocation, all of which are associated with co-stimulatory molecules expression
Cahill et al., J Biol Chem 2008
:
Neither inhibition of PI
3-kinase/AKT nor IKKalphaT23A overexpression
affected IkappaBalpha degradation in response to IL-1
Chen et al., Thromb Haemost 2008
(MAP Kinase Signaling System) :
In conclusion, our data indicated that inhibition of NF-kappaB through stabilization of
IkappaB-alpha and
activation of
Akt phosphorylation may mediate the inhibitory effect of Adp on TF expression ; but the enhancement effect of Adp on the TFPI production might occur via translational rather than transcriptional regulation
Gao et al., Mol Biol Rep 2009
(Insulinoma) :
The molecular mechanism of TIMP-1 inhibition of resistin mediated cytotoxicity appeared to involve
Akt phosphorylation and
activation of
IkB-alpha phosphorylation
Fong et al., Lung Cancer 2009
(Adenocarcinoma...) :
The OPN mediated increases in IKK alpha/beta,
IkappaBalpha and p65 Ser ( 536 ) phosphorylation were
inhibited by Ly294002,
Akt inhibitor and PD98059
Sag et al., J Immunol 2008
(Inflammation) :
In addition, we found that AMPK negatively regulated LPS induced
IkappaB-alpha degradation and positively
regulated Akt activation, accompanied by inhibition of glycogen synthase kinase beta and activation of CREB
Ko et al., Eur J Pharmacol 2010
:
Furthermore, inflexin inhibited the degradation of
IkappaB-alpha and the
activation of NF-kappaB, p65 and
Akt , while the MAPKs signal pathway was not affected
Tse et al., Mol Immunol 2010
(Breast Neoplasms) :
Previous studies indicated that VD ( 3 ) can either activate or inhibit NF-kappaB via
Akt induced
I kappaB alpha phosphorylation and increase in I kappaB alpha synthesis respectively ... We showed that VD ( 3 ) induced VDR dependent I kappaB alpha expression but still able to lead on transient NF-kappaB p65 nuclear translocation through
Akt induced
I kappaB alpha phosphorylation
Béraud et al., Proc Natl Acad Sci U S A 1999
:
Wortmannin did not inhibit tyrosine phosphorylation of
IkappaB-alpha or alter the stability of the PI3-kinase complex but
inhibited Akt kinase activation in response to pervanadate