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AKT1 — GPER1

Text-mined interactions from Literome

Zhang et al., Zhonghua Fu Chan Ke Za Zhi 2012 (Endometrial Neoplasms) : [ Effect of GPER on the activation of PI3K/Akt induced by 17ß-estradiol in endometrial carcinoma cells ]
Fujiwara et al., Journal of ovarian research 2012 : The expression of both GPR30 and EGFR is associated with a poor outcome in ovarian cancer, and GPR30 increases the phosphorylation of Akt via the EGFR in ovarian cancer cells
Garand et al., Blood Coagul Fibrinolysis 2013 : Indeed, we found that the effect of estrogen was independent of the estrogen receptor and was mediated through a novel signaling pathway dependent on phosphatidylinositol 3-kinase and Akt that did not involve GPR30
Guo et al., Zhonghua Fu Chan Ke Za Zhi 2013 : [ Influence of pertussis toxin on GPER mediated activation of phosphatidylinositol 3-kinase/protein kinase B signaling induced by 17ß-estradiol in endometrial carcinoma cells ] ... Changes of levels of GPER , ERa and ERß protein and the activation of Akt protein were observed by western blot in the two cells after they were treated by PTX for 30 minutes at different concentrations ( 0, 0.1, 0.5, 1.0 µg/ml ), and then co-stimulated with with 1x10 ( -6 ) mol/L 17ß-E2 respectively at different time ( Ishikawa 30 minutes, HEC-1A 15 minutes )