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BAX — STAT3
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Moodley et al., Am J Respir Cell Mol Biol 2003
(MAP Kinase Signaling System...) :
Using RNase protection assays, we showed that IL-6 enhanced Fas induced apoptosis and expression of
Bax in normal-Fb, but inhibited apoptosis and induced expression of Bcl-2 in IPF-Fb. Densitometry of Western blots revealed a Bcl-2/Bax ratio 0.15 +/- 0.01 in normal-Fb compared with 12.05 +/- 1.0 in IPF-Fb. Upregulation of Bcl-2 in normal-Fb and Bax in IPF-Fb were both
STAT-3 dependent
Porras et al., Mol Biol Cell 2004
(MAP Kinase Signaling System) :
Phosphorylation of the transcription factor
STAT3 on Ser-727, mediated by the extracellular signal regulated kinase MAP kinase pathway, may
contribute to the decrease in both
Bax and Fas expression in p38 alpha-/- cells
Lee et al., Int J Cancer 2008
(Carcinoma, Squamous Cell...) :
A signal network
involving coactivated NF-kappaB and
STAT3 and altered p53 modulates
BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas
Khan et al., BioMed research international 2013
(Liver Neoplasms) :
This alantolactone induced apoptosis was found to be associated with GSH depletion,
inhibition of
STAT3 activation, ROS generation, mitochondrial transmembrane potential dissipation, and increased
Bax/Bcl-2 ratio and caspase-3 activation