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IRS2 — SIRT1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Zhang et al., J Biol Chem 2007
(Diabetes Mellitus) :
The direct
involvement of
SirT1 in insulin induced
insulin receptor substrate-2 tyrosine phosphorylation ... Suppression of
SirT1 activity also selectively
inhibited insulin induced tyrosine phosphorylation of
insulin receptor substrate 2 (IRS-2) , whereas it had minimal effect on that of IRS-1 ... These results suggest a possible regulatory
effect of
SirT1 on insulin induced tyrosine phosphorylation of
IRS-2 , a vital step in insulin signaling pathway, through deacetylation of IRS-2 protein
Li et al., Cell Metab 2008
:
SirT1 inhibition
reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons