Kilbourn et al., J Natl Cancer Inst 1992
(Hypotension) :
on the immunorestorative and antineoplastic activity of IL-1, N omega-amino-L-arginine ( NAA ) or N omega-monomethyl-L-arginine ( NMA ), inhibitors of nitric oxide synthase , were added to either cultures of IL-1 dependent T cells or A375 melanoma cells exposed to IL-1
Surendran et al., Med Hypotheses 2010
(Canavan Disease) :
Therefore we hypothesize that upregulation of NAA stimulates NOS and the resulting nitric oxide toxicity induces ASPA mutations and protein interaction to result pathophysiological abnormalities seen in patients with CD