◀ Back to NOS1
CAPN14 — NOS1
Text-mined interactions from Literome
Su et al., Am J Physiol Lung Cell Mol Physiol 2000
(Anoxia) :
Role of
calpain in hypoxic inhibition of
nitric oxide synthase activity in pulmonary endothelial cells
White et al., J Neurol Sci 2000
(Brain Ischemia...) :
This allows a large increase in cytosolic Ca ( 2+ ) associated with activation of mu-calpain, calcineurin, and phospholipases with consequent proteolysis of
calpain substrates ( including spectrin and eIF4G ),
activation of
NOS and potentially of Bad, and accumulation of free arachidonic acid, which can induce depletion of Ca ( 2+ ) from the ER lumen
Stalker et al., FASEB J 2003
:
Immunoprecipitation studies revealed that glucose induces loss of NO via a
calpain dependent decrease in the association of hsp90 with endothelial
nitric oxide synthase
Cui et al., Am J Respir Cell Mol Biol 2005
:
Involvement of
calpain-calpastatin in cigarette smoke
induced inhibition of lung endothelial
nitric oxide synthase
Dong et al., J Cell Mol Med 2009
:
Activation of protease
calpain by oxidized and glycated LDL
increases the degradation of endothelial
nitric oxide synthase
Brorson et al., Stroke 1995
:
Among various processes that have been thought to mediate the toxic effects of glutamate are activation of the Ca ( 2+ ) -dependent proteases
calpain I and II and the
activation of
nitric oxide synthase