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MMP13 — RLN3
Text-mined interactions from Literome
Naqvi et al., Arthritis Res Ther 2005
:
Previously, we showed that
relaxin dose-dependently
induces matrix metalloproteinase ( MMP ) expression in isolated joint fibrocartilaginous cells
Goldsmith et al., Ann N Y Acad Sci 2005
:
In addition,
relaxin negatively
regulates expression of endometrial
matrix metalloproteinases ( MMP ) , causing decreased endometrial levels of MMP-1 and MMP-3 proteins and increased protein levels of their endogenous inhibitor, tissue inhibitor of metalloproteinase 1 ... The negative
effects of
relaxin on
MMP expression in the endometrium are in distinct contrast to the positive regulation of MMPs previously shown in fibroblasts from other tissues including the cervix
Silvertown et al., Endocrinology 2006
(Lung Diseases) :
Taken together, this study provides proof-of- principle that
relaxin gene expression targeted to the mouse lungs can
result in enhanced
MMP activity offering potential for alleviating disease conditions characterized by dysregulation of extracellular matrix protein accumulation
Henneman et al., Arch Oral Biol 2008
:
Previous studies have indicated that
MMP production can be
stimulated by the hormone
relaxin
Ahmad et al., Mol Cell Endocrinol 2012
:
We determined the precise
role of
relaxin family peptide ( RXFP ) receptors-1 and -2 in the regulation of
MMP-9 and -13 by relaxin, and delineated the signaling cascade that contributes to relaxin 's modulation of MMP-9 in fibrocartilaginous cells ... Suppression or overexpression of RXFP2 resulted in no changes in the
relaxin induced
MMP-9 and -13