Gene interactions and pathways from curated databases and text-mining

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LOX — MAPK3

Text-mined interactions from Literome

de Bernardo et al., J Neurochem 2004 : MEK-1/2 and lipoxygenase (LOX) inhibitors, as well as ascorbic acid, prevent ERK-1/2 activation and neuronal loss, but the inhibition of nitric oxide sintase (NOS), cyclo-oxygenase (COX), c-Jun N-terminal kinase (JNK) and p38 mitogen activated protein kinase ( p38 MAPK ) does not have protective effects
Zhang et al., J Neurosci 2004 : Inhibition of 12-LOX blocked the activation of p38 MAPK and caspase-3
Voloshenyuk et al., Cytokine 2011 (MAP Kinase Signaling System) : Induction of cardiac fibroblast lysyl oxidase by TGF-ß1 requires PI3K/Akt, Smad3, and MAPK signaling ... The increase of LOX protein in response to TGF-ß1 was prevented by inhibitors of PI3K, Smad3, p38-MAPK , JNK and ERK1/2