◀ Back to PAK1
GIT1 — PAK1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Aurora A signaling:
GIT1/betaPIX/PAK1 complex (GIT1-ARHGEF7-PAK1)
→
PAK1/Aurora A complex (PAK1-AURKA)
(modification, collaborate)
Zhao et al., Mol Cell 2005*
Evidence: physical interaction
-
NCI Pathway Database Aurora A signaling:
GIT1/betaPIX/PAK1 complex (GIT1-ARHGEF7-PAK1)
→
Aurora A (AURKA)
(modification, collaborate)
Zhao et al., Mol Cell 2005*
Evidence: physical interaction
-
NCI Pathway Database Aurora A signaling:
GIT1/betaPIX/PAK1 complex (GIT1-ARHGEF7-PAK1)
→
GIT1/betaPIX complex (GIT1-ARHGEF7)
(modification, collaborate)
Zhao et al., Mol Cell 2005*
Evidence: physical interaction
-
NCI Pathway Database Aurora A signaling:
PAK1/Aurora A complex (PAK1-AURKA)
→
GIT1/betaPIX complex (GIT1-ARHGEF7)
(modification, collaborate)
Zhao et al., Mol Cell 2005*
Evidence: physical interaction
-
NCI Pathway Database Aurora A signaling:
PAK1 (PAK1)
→
GIT1 (GIT1)
(modification, collaborate)
Zhao et al., Mol Cell 2005*
Evidence: assay, physical interaction
-
NCI Pathway Database Aurora A signaling:
PAK1 (PAK1)
→
GIT1/betaPIX/PAK1 complex (GIT1-ARHGEF7-PAK1)
(modification, collaborate)
Zhao et al., Mol Cell 2005*
Evidence: assay, physical interaction
-
NCI Pathway Database Aurora A signaling:
GIT1 (GIT1)
→
GIT1/betaPIX/PAK1 complex (GIT1-ARHGEF7-PAK1)
(modification, collaborate)
Zhao et al., Mol Cell 2005*
Evidence: assay, physical interaction
-
NCI Pathway Database Aurora A signaling:
GIT1/betaPIX/PAK1 complex (GIT1-ARHGEF7-PAK1)
→
betaPIX (ARHGEF7)
(modification, collaborate)
Zhao et al., Mol Cell 2005*
Evidence: assay, physical interaction
-
Reactome Reaction:
GIT1
→
PAK1
(indirect_complex)
Bokoch et al., Annu Rev Biochem 2003, Zhang et al., J Neurosci 2005
-
Reactome Reaction:
GIT1
→
PAK1
(reaction)
Bokoch et al., Annu Rev Biochem 2003, Zhang et al., J Neurosci 2005
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Peters et al., G3 (Bethesda, Md.) 2013
:
Second, PIX-1 and
GIT-1 function in the same role as PAK-1, and
PAK-1 interaction with PIX-1 is
required for PAK-1 activity ; thus, PAK-1 functions noncanonically
Aslan et al., Am J Physiol Cell Physiol 2013
:
Platelet activation by thrombin triggered the
PAK dependent phosphorylation of
GIT1 , GEFH1, and other PAK effectors, including LIMK1 and Merlin