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IGF2 — TCF3
Text-mined interactions from Literome
Palamarchuk et al., FEBS Lett 1999
:
In the present study, we demonstrate that a liver enriched
transcription factor , hepatocyte nuclear factor 3beta ( HNF-3beta ), is an
activator of the chum salmon
IGF-II gene
Morali et al., Oncogene 2001
:
We can show that ( 1 ) IGF-II induces a rapid epithelium to mesenchymal transition ; ( 2 ) IGF1R, the receptor for IGF-II, belongs to the same membrane complex as E-cadherin and beta-catenin ; ( 3 ) IGF-II induces a redistribution of beta-catenin from the plasma membrane to the nucleus and an intracellular sequestration and degradation of E-cadherin ; ( 4 )
IGF-II induces the transcription of
beta-catenin/TCF-3 target genes
Markljung et al., PLoS Biol 2009
(Genetic Diseases, Inborn) :
ZBED6, a novel
transcription factor derived from a domesticated DNA transposon
regulates IGF2 expression and muscle growth
Borensztein et al., Development 2013
:
In addition,
Igf2 also negatively
regulates Myod expression, possibly by reducing the expression of the Srf
transcription factor , a known Myod activator
Zvibel et al., J Cell Physiol 1995
(Carcinoma, Hepatocellular...) :
The
transcription factor HNF-3 beta mRNA and protein levels of the bile duct markers, CK19 and GGT, were also increased in the
presence of
IGF II
Castillo et al., Endocrinology 1997
:
As analyzed by Western blot,
IGF-1 did not alter GHF-1/Pit-1 protein levels in GH4C1 cells but
reduced the levels of the
transcription factor in GH3 cells