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FOS — SFTPC
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Berger et al., Proc Natl Acad Sci U S A 1995
(Niemann-Pick Diseases) :
Here we show that
SPC increased specific DNA binding activity of transcription activator
AP-1 in electrophoretic mobility-shift assays ... Since the increase in AP-1 binding activity preceded the increase in c-fos mRNA, posttranslational modifications may be important in mediating the early
SPC induced increases in
AP-1 DNA binding activity ... Since the expression of many proteins with diverse functions is known to be regulated by AP-1,
SPC induced activation of
AP-1 may contribute to the pathophysiology of Niemann-Pick disease
Berger et al., Biochim Biophys Acta 1998
:
We previously demonstrated that the sphingolipid,
sphingosylphosphocholine (SPC) increased DNA binding activity of
AP-1 proteins accompanying cellular proliferation