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PTGS2 — RHO
Text-mined interactions from Literome
Slice et al., J Biol Chem 1999
:
Galpha(13) stimulates
Rho dependent activation of the
cyclooxygenase-2 promoter
Slice et al., Biochem Biophys Res Commun 2000
:
Differential
regulation of
COX-2 transcription by Ras- and
Rho-family of GTPases ... This demonstrates
Rho dependent transactivation of the
COX-2 promoter through novel trans acting elements and suggests that, in NIH 3T3 cells, signaling by small GTPases that result in COX-2 expression is not through a sequential pathway from Cdc42 to Rac to Rho, but rather through independent, parallel signaling pathways
Hahn et al., Biochem J 2002
:
The
role of
Rho proteins in lysophosphatidic acid (LPA) mediated induction of
cyclo-oxygenase-2 (Cox-2) was investigated in renal mesangial cells
Slice et al., J Cell Physiol 2003
(Calcium Signaling) :
Galphaq signaling is required for
Rho dependent transcriptional activation of the
cyclooxygenase-2 promoter in fibroblasts ... However, the specific role of heterotrimeric guanine nucleotide binding regulatory proteins ( G-proteins ) that are coupled to the GRP receptor in
Rho dependent
COX-2 expression has not been elucidated ... Activation of endogenous
Rho by expression of Onco-lbc or expression of Rho A Q63L
resulted in
COX-2 promoter activation in Galpha ( q/11 ) deficient cells ... Inhibition of
Rho by Clostridium botulinum C3 toxin
blocked COX-2 promoter induction
Schmeck et al., Inflammation 2003
:
Rho protein inhibition
blocks cyclooxygenase-2 expression by proinflammatory mediators in endothelial cells
Chang et al., J Cell Biochem 2005
:
Here we investigate the
role of coordinate activation of Ras and
Rho GTPases in the induction of
COX-2 ... Together, our data suggest that constitutively active oncogenic Ras and
Rho coordinately
stimulate COX-2 expression whereas transient activation of Ras but not RhoA or Rac1 mediates the induction of COX-2 in response to serum
Hirota et al., Am J Physiol Gastrointest Liver Physiol 2012
:
However, inhibition of either Src tyrosine kinase signaling by PP2,
Rho kinase signaling by Y27632, or phosphatidylinositol 3 (PI3) kinase signaling by LY294002
prevented 2fLI induced
COX-2 expression