Sawada et al., Nihon rinsho. Japanese journal of clinical medicine 2001
(Stroke) :
Importantly, statin inhibition of Rho ( 1 ) attenuates the infarct size in a rat model of brain ischemia via the elevation of eNOS expression, and ( 2 ) suppresses vascular smooth muscle proliferation through up-regulation of CDK inhibitor p27kip1
Cosentino et al., Recenti Prog Med 2003
(Acute Disease...) :
Recent findings on statin induced inhibition of Rho/Rho-kinase and activation of Akt provide new insights into the protective action of statins in acute coronary syndromes
Riches et al., Int J Biochem Cell Biol 2013
:
SMC manipulation through RhoA gene silencing, Rho kinase inhibition , statin pre-treatment, aVß3 neutralising antibody and tyrosine kinase inhibition all markedly inhibited apo(a) mediated SMC migration