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ARHGEF1 — RHO

Text-mined interactions from Literome

Bourguignon et al., J Biol Chem 2003 (Breast Neoplasms...) : The binding of HA to MDA-MB-231 cells stimulates p115RhoGEF mediated RhoA signaling and Rho kinase (ROK) activity, which, in turn, increases serine/threonine phosphorylation of the adaptor protein, Gab-1 ( Grb2 associated binder-1 )
Holinstat et al., J Biol Chem 2003 : Inhibition of PKCalpha dependent p115RhoGEF phosphorylation prevented the thrombin induced Rho activation, indicating that the response occurred downstream of PKCalpha phosphorylation of p115RhoGEF ... The regulator of G-protein signaling domain of p115RhoGEF, a GTPase activating protein for G12/13, also prevented thrombin induced Rho activation, indicating the parallel requirement of G12/13 in signaling Rho activation via p115RhoGEF
Grabocka et al., Oncogene 2005 : Interestingly, an alpha ( 13 ) mutant where a conserved Gly was mutated to a Ser ( G205S ) retained its ability to bind to p115RhoGEF, induce p115RhoGEF recruitment to the PM, and activate Rho dependent signaling, even though identical Gly to Ser mutations in other alpha disrupt their interaction with regulator of G-protein signaling (RGS) proteins