UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

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MLST8 — RRAGD

Pathways - manually collected, often from reviews:

NCI Pathway Database mTOR signaling pathway: RagA-B/GTP/RagC-D/GDP complex (RRAGA_RRAGB-RRAGC_RRAGD) → mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR) (modification, activates)
Sancak et al., Science 2008, Kim et al., Nat Cell Biol 2008
Evidence: mutant phenotype, assay, physical interaction