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HTR1A — MAPK3

Text-mined interactions from Literome

Chen et al., Eur J Pharmacol 2002 : 5-HT1A receptor mediated regulation of mitogen activated protein kinase phosphorylation in rat brain ... We determined whether 5-HT(1A) receptors activate Erk1/2 in rat brain in vivo, as they do in recombinant cell lines
Kushwaha et al., Eur J Neurosci 2005 : In undifferentiated RN46A cells stably transfected with the wild-type 5-HT1A receptor, 5-HT1A receptor activation inhibited forskolin induced cyclic adenosine monophosphate ( cAMP ) formation ( by 50 % ), increased [Ca2+ ] i, and induced a novel inhibition ( up to 60 % ) of phospho-p42/p44-mitogen activated protein kinase ( MAPK )
Bonnefont et al., Mol Pharmacol 2007 (Pain) : Indeed, down-regulation of sst3R mRNA depends on acetaminophen elicited, 5-HT1A receptor dependent increase in neuronal extracellular signal regulated kinase 1/2 ( ERK1/2 ) activities that mediate antinociception
Debata et al., Biochem Biophys Res Commun 2010 : Erk1/2 dependent phosphorylation of PKCalpha at threonine 638 in hippocampal 5-HT(1A) receptor mediated signaling
Garnovskaya et al., Biochemistry 1996 : Ras dependent activation of fibroblast mitogen activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit initiated pathway ... These data demonstrate that the 5-HT1A receptor mediates MAPK activity by convergence upon a common activation pathway that is shared with receptor tyrosine kinases
Garnovskaya et al., J Biol Chem 1997 : Acceleration of proton efflux was not inhibited by sequestration of G protein betagamma-subunits, a maneuver that blocked 5-HT1A receptor activation of mitogen activated protein kinase
Della Rocca et al., J Biol Chem 1999 : We conclude that CAM dependent activation of Erk1/2 through the 5-HT1A receptor reflects its role in endocytosis of the receptor, which is a required step in the activation of MEK and subsequently Erk1/2