Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
EP300
→
MAPK3
(increases, MAPK3 Activity, EP300 Activity)
Goel et al., Mol Cell Biol 2003* Evidence: Furthermore, oncogenic HER2/Neu, which induces phosphorylation and thereby activation of ER81, was less able to activate acetylation-deficient ER81 mutants, indicating that both acetyltransferase and protein kinase-specific regulatory mechanisms control ER81 activity. Importantly, HER2/Neu overexpression stimulates the ability of p300 to acetylate ER81, likely by inducing phosphorylation of p300 through the Ras-->Raf-->mitogen-activated protein kinase pathway.