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FGF2 — IGF2

Text-mined interactions from Literome

Zhang et al., Lab Invest 1999 (Asthma) : After epithelial perturbation, basic fibroblast growth factor , platelet derived growth factor, IGF-1 , transforming growth factor-beta2, and endothelin-1 levels increased in culture supernatants
Cao et al., Zhonghua Yan Ke Za Zhi 1997 : ( 1 ) EGF, b-FGF , IGF-I significantly increased the DNA 6.6-12.2 times in human RPE cells in comparison with the control, the rank order of potency of the factors being EGF > b-FGF > IGF-I ... ( 1 ) EGF, b-FGF , IGF-I significantly increased the DNA 6.6-12.2 times in human RPE cells in comparison with the control, the rank order of potency of the factors being EGF > b-FGF > IGF-I
Belik et al., Can J Physiol Pharmacol 2000 : IGF-2 mRNA levels significantly declined in both arteries from neonatal to adult, but bFGF increased only in the pulmonary artery during this transition
Boulle et al., Endocrinology 2000 (Adrenal Cortex Neoplasms) : Recombinant human FGF-2 stimulated the proliferation of adrenocortical tumor cells in a dose- and time dependent manner, with a maximal effect at a concentration of about 1 ng/ml. Treatment of H295R cells with 10 ng/ml FGF-2 for 7 days had no significant effect on IGF-II messenger RNA levels ... Cell cultures in the presence of brefeldin A ( 1 microg/ml ), a specific inhibitor of protein secretion, suggested that FGF-2 did not increase IGF-II synthesis but instead inhibited the secretion of pro-IGF-II from H295R cells, thereby impairing the final steps of IGF-II processing to the mature 7.5-kDa peptide ... Altogether, these results indicate that FGF-2 is mitogenic for NCI H295R tumor cells and regulates the expression of both IGF-II and IGFBP-2 in this tumor model
Bendall et al., Nature 2007 : IGF-II is expressed by hdFs in response to FGF , and alone was sufficient in maintaining human ES cell cultures
Montes et al., Cell Res 2009 : A paracrine regulation was recently proposed in human embryonic stem cells ( hESCs ) grown in mouse embryonic fibroblast (MEF) conditioned media ( MEF-CM ), where hESCs spontaneously differentiate into autologous fibroblast-like cells to maintain culture homeostasis by producing TGF-beta and insulin-like growth factor-II (IGF-II) in response to basic fibroblast growth factor (bFGF)
Park et al., Growth Factors 2009 : bFGF also increased the expression of FGFR, which in turn increased expression of insulin-like growth factor ( IGFs )
Johnson et al., Exp Cell Res 1995 : In addition, specific binding of FGF2 to 48-h cultures of adult satellite cells was not stimulated by FGF2, IGF-1 , IGF-2, PDGF-BB, or TGF-beta 2, and specific binding was significantly decreased ( P < 0.05 ) by FGF2 and TGF-beta 2
Scheinowitz et al., Int J Cardiol 1997 (Disease Models, Animal...) : IGF has been found to promote physiological forms of cardiac hypertrophy, and FGF induces neovascularization
Gangji et al., Endocrinology 1998 : We also determined mechanisms involved in the regulation of IGF-II by platelet derived growth factor (PDGF) BB, fibroblast growth factor-2 (FGF-2), and transforming growth factor (TGF) beta1