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ADRB2 — GRK4

Pathways - manually collected, often from reviews:

• KEGG Endocytosis: ADRBK1/ADRBK2/GRK1/GRK4/GRK5/GRK6/GRK7 → ADRB1/ADRB2/ADRB3/CCR5/CXCR1/CXCR2/CXCR4/F2R (protein-protein, phosphorylation)
  

Text-mined interactions from Literome

Mak et al., Eur J Pharmacol 2002 (Cystic Fibrosis...) : These data suggest that the increase in GRK activity may be one of the mechanisms underlying alterations in the coupling between beta2-adrenoceptor and adenylyl cyclase via G-protein and may thus contribute to the downregulation of beta2-adrenoceptor in cystic fibrosis lung
Mak et al., Br J Pharmacol 2002 : In light of data obtained in this study, we propose that both the decrease in AC activity and the increase in GRK activity, which are reversed by dexamethasone, may underlie beta(2)-adrenoceptor desensitization
Freeman et al., Biochemistry 2002 : Beta 2-adrenergic receptor stimulated , G protein coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2
Bawa et al., Br J Pharmacol 2003 : Desensitization of alpha 2A-adrenoceptor signalling by modest levels of adrenaline is facilitated by beta 2-adrenoceptor dependent GRK3 up-regulation