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IL11 — STAT3

Text-mined interactions from Literome

O'Brien et al., J Biol Chem 1999 : STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130 utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroid hormone
Walton et al., Blood 2002 : Heparin was found to enhance both IL-11 induced STAT3-DNA complex formation and transactivation without altering either STAT3 ( signal transducer and activator of transcription-3 ) tyrosine or serine phosphorylation
Dimitriadis et al., Endocrinology 2006 : IL-11 stimulated the phosphorylation ( p ) of STAT3 and SOCS3 mRNA and protein
Rajgopal et al., J Biol Chem 2006 (MAP Kinase Signaling System) : When taken together, these findings suggest that heparin enhances IL-11 induced STAT3 activation and thus osteoclast formation, by a mechanism that is independent of STAT3 Ser-727 phosphorylation but that involves up-regulation of the MAPK pathway
Bao et al., Mol Endocrinol 2006 : We also found that IL-11 activates Janus kinase 2 (Jak2) and induces rapid phosphorylation, nuclear translocation, and promoter binding activity of Stat3 in decidual cells, whereas Jak1, Tyk2, and Stat5 activities are not affected
Kimura et al., Cytokine 2007 (Reperfusion Injury) : IL-11 stimulation resulted in the translocation of phosphorylated STAT3 into nuclei
Jackson et al., J Pathol 2007 (Adenocarcinoma...) : We addressed this using an in vitro approach, demonstrating that recombinant human IL-11 activates STAT3 and concomitantly increases proliferation of MKN28 gastric epithelial cells
Yap et al., Reproductive biology and endocrinology : RB&E 2010 (Carcinoma...) : IL11 increased pSTAT3/STAT3 in all tumour cell lines, while SOCS3 abundance was increased only in one tumour cell line
Ozawa et al., Journal of ophthalmology 2011 : In innate chorioretinal inflammation, interleukin-6 family ligands induce STAT3 activation in photoreceptors, which causes UPS mediated excessive degradation of the visual substance, rhodopsin
Nishina et al., Science signaling 2012 : IL-11 that was secreted by the dying cells then induced the phosphorylation of the transcription factor STAT3 in adjacent healthy hepatocytes, which resulted in their compensatory proliferation
Shin et al., Carcinogenesis 2012 (Neoplasm Invasiveness) : These results suggest that both the PI3K and Raf pathways are necessary for the expression of IL-11 in oncogenic Ras mutated cells, and that JNK, p38 and Stat3 also contribute to oncogenic Ras induced IL-11 expression
Calon et al., Cancer Cell 2012 (Colorectal Neoplasms...) : Secretion of IL11 by TGF-ß stimulated cancer associated fibroblasts ( CAFs ) triggers GP130/STAT3 signaling in tumor cells