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EPX — STAT3
Text-mined interactions from Literome
Kirito et al., Blood 2002
(Leukemia) :
In addition, Jak2 and Fes tyrosine kinases were involved in
EPO induced
activation of Stat1 and
Stat3 ... These results indicate that Stat1 and
Stat3 are
activated by
EPO via distinct mechanisms from Stat5
Halupa et al., Blood 2005
(Anemia) :
EPO activates signal transducer and activator of transcription 1 ( STAT1 ),
STAT3 , and STAT5a/b transcription factors in erythroid cell lines
Kretz et al., Mol Cell Neurosci 2005
(Optic Nerve Injuries) :
EPO induced
Stat3 phosphorylation in RGCs, and inhibition of Jak2/Stat3 abolished EPO induced growth
Wincewicz et al., Folia Histochem Cytobiol 2009
(Breast Neoplasms...) :
EPO receptor
activates STAT3
Souvenir et al., Neurobiol Dis 2011
(Cerebral Infarction...) :
Our data showed that
EPO significantly
increased cell survival, associated with increased TIMP-1 activity, phosphorylation of JAK-2 and
STAT-3 , and decreased MMP-9 activity in vivo and in vitro
Kirito et al., J Biol Chem 1997
:
However,
EPO hardly
activated Stat1alpha and
Stat3 in UT-7/GM, which is a subline of UT-7 that grows slightly in response to EPO ... Thus, although Stat1alpha,
Stat3 , and Stat5 proteins are
activated by GM-CSF, IL-3, and
EPO , our data suggest that each STAT protein has a distinctive role in the actions of cytokines