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MDM2 — NPM1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
MDM2
—
NPM1
(physical association, affinity chromatography technology)
Kurki et al., Cancer Cell 2004*
-
IRef Biogrid Interaction:
MDM2
—
NPM1
(direct interaction, pull down)
Kurki et al., Cancer Cell 2004*
-
IRef Biogrid Interaction:
MDM2
—
NPM1
(direct interaction, unspecified method)
Nicholson et al., J Proteome Res 2012*
-
IRef Biogrid Interaction:
MDM2
—
NPM1
(physical association, affinity chromatography technology)
Nicholson et al., J Proteome Res 2012*
-
IRef Hprd Interaction:
NPM1
—
MDM2
(in vivo)
Kurki et al., Cancer Cell 2004*
-
IRef Hprd Interaction:
NPM1
—
MDM2
(in vitro)
Kurki et al., Cancer Cell 2004*
-
IRef Intact Interaction:
MDM2
—
NPM1
(physical association, anti bait coimmunoprecipitation)
Kurki et al., Cancer Cell 2004*
-
IRef Intact Interaction:
MDM2
—
NPM1
(physical association, pull down)
Kurki et al., Cancer Cell 2004*
-
IRef Intact Interaction:
MDM2
—
NPM1
(direct interaction, pull down)
Ji et al., EMBO Rep 2012*
-
IRef Intact Interaction:
Complex of MDM2-TP53-NPM1-NPM1
(association, anti bait coimmunoprecipitation)
Kurki et al., Cancer Cell 2004*
-
IRef Intact Interaction:
Complex of TP53-MDM2-NPM1
(association, anti bait coimmunoprecipitation)
Ji et al., EMBO Rep 2012*
Text-mined interactions from Literome
Kurki et al., Cancer Cell 2004
(Osteosarcoma) :
Here we show that
NPM is a UV damage response protein that undergoes nucleoplasmic redistribution and
regulates p53 and
HDM2 levels and their interaction
Ando et al., J Biol Chem 2013
:
Our data suggest that enhanced
HDM2 expression
induced by mutant
NPM1 may have a role in MEF/ELF4 dependent leukemogenesis