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ATF4 — CASP12
Text-mined interactions from Literome
Lin et al., Anticancer Res 2007
(Nasopharyngeal Neoplasms) :
Moreover, for the first time in NPC cells it was demonstrated that the pathway involved in rhein induced apoptosis is caspase dependent, presumably through the endoplasmic reticulum ( ER ) stress pathway, as shown by an increase in the levels of glucose regulated protein 78 (GRP 78), PKR-like ER kinase (PERK),
activating transcription factor 6 ( A TF6 ) and CCAA TIenhancer binding protein homologous protein ( CHOP ) as well as the
activation of
caspase-3 , -8, -9 and -12
Zhang et al., Neurosci Lett 2010
:
These results indicate that both the PERK/eIF2
alpha/ATF4 ISR and
activation of
caspase-12 may be involved in apoptosis of spinal cord astrocytes induced by OGSD/restoration
Fan et al., Brain Res 2013
:
Edaravone protects against glutamate induced
PERK/EIF2a/ATF4 integrated stress response and
activation of
caspase-12