Gene interactions and pathways from curated databases and text-mining
PIK3CA: top 25 interacting genes (chr3:178866310-178952497)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only PIK3CA-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
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Less-frequently mentioned interactions with PIK3CA, not among the Top 25
Other genes interacting with PIK3CA. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

EGF ▸ RAC1 ▸ EGFR ▸ IL6 ▸ NOS3 ▸ TNF ▸ MMP9 ▸
IRS1 ▸ LEP ▸ PI3 ▸ PTGS2 ▸ HMOX1 ▸ IL8 ▸ ANXA6 ▸
FOXO3 ▸ IRF6 ▸ CASP3 ▸ CASP1 ▸ CASP9 ▸ SRC ▸ CASP7 ▸
CASP14 ▸ CASP12 ▸ BCR ▸ CASP16 ▸ CASP10 ▸ CASP5 ▸ CASP8 ▸
CASP2 ▸ CASP4 ▸ BCL2 ▸ CASP6 ▸ HIF1A ▸ GSK3B ▸ IL12A ▸
IL2 ▸ IL12B ▸ JUN ▸ HGF ▸ IL10 ▸ FOXO1 ▸ NOS2 ▸
CCND1 ▸ RAC2 ▸ FGF2 ▸ STAT3 ▸ CD28 ▸ MLST8 ▸ NGF ▸
TLR4 ▸ KRAS ▸ CTNNB1 ▸ CBFA2T2 ▸ MMP2 ▸ TP53 ▸ RAF1 ▸
NOX1 ▸ ESR1 ▸ NOX4 ▸ BDNF ▸ NOX5 ▸ TLR2 ▸ IRS2 ▸
PTPN11 ▸ RAC3 ▸ NOX3 ▸ HRAS ▸ CDC42 ▸ RPTOR ▸ MAP2K1 ▸
CREB5 ▸ JAK2 ▸ RHOA ▸ ARHGEF7 ▸ CD79A ▸ IL1B ▸ CREB1 ▸
CREB3 ▸ CRK ▸ IGF2 ▸ PRKAA2 ▸ PRKAG2 ▸ GRAP2 ▸ PRKAB2 ▸
CD79B ▸ CDKN1A ▸ PRKAA1 ▸ PRKAG1 ▸ PRKAB1 ▸ MCL1 ▸ IFI27 ▸
MMP14 ▸ PRKAR2B ▸ PRKACB ▸ PRKAR1B ▸ CBL ▸ GAB1 ▸ PRKACG ▸
BMP2 ▸ PRKAR1A ▸ PRKAR2A ▸ HSPG2 ▸ SETD2 ▸ PLCG1 ▸ PDGFB ▸
SLC2A4 ▸ FAS ▸ SLC25A16 ▸ TLR5 ▸ PARP1 ▸ RAD50 ▸ IFNG ▸
STAT1 ▸ SMAD2 ▸ FOS ▸ BCL10 ▸ MRE11A ▸ TCF23 ▸ TMED7 ▸
MMP13 ▸ IL3 ▸ PIK3CD ▸ ESR2 ▸ CXCL12 ▸ TERF2IP ▸ PRKCA ▸
JAK1 ▸ RPS6KB1 ▸ TCF25 ▸ AHSA1 ▸ XIAP ▸ POT1 ▸ TCF20 ▸
TINF2 ▸ IL17A ▸ TCF4 ▸ PDGFRB ▸ TCF21 ▸ TCF15 ▸ TCF3 ▸
SYK ▸ ACD ▸ TCF12 ▸ XRCC6 ▸ TERF2 ▸ TCF19 ▸ TCF7 ▸
MMP10 ▸ PIK3CB ▸ TCF24 ▸ BAX ▸ PHKA2 ▸ IL4 ▸ IGF1R ▸
PTK2 ▸ PIK3R1 ▸ XRCC5 ▸ TLR3 ▸ MMP7 ▸ ANGPT2 ▸ TERF1 ▸
MMP12 ▸ TGFB1 ▸ PLD2 ▸ FOXO4 ▸ TLR1 ▸ MMP20 ▸ MMP1 ▸
SREBF1 ▸ RAB5A ▸ FOXO6 ▸ IKBKG ▸ PLAU ▸ MYD88 ▸ SLC2A1 ▸
SP1 ▸ JAK3 ▸ MMP11 ▸ CTGF ▸ ZGLP1 ▸ MMP24 ▸ TLR6 ▸
MMP8 ▸ MMP27 ▸ GJA1 ▸ MMP25 ▸ ICAM1 ▸ MMP26 ▸ MYLIP ▸
MMP17 ▸ EIF4EBP1 ▸ ILK ▸ MMP16 ▸ TLR10 ▸ PRL ▸ TLR9 ▸
MMP19 ▸ MMP3 ▸ VCAM1 ▸ TLR7 ▸ MMP21 ▸ MMP15 ▸ NOS1 ▸
MMP28 ▸ TLR8 ▸ STK25 ▸ HRG ▸ CDH1 ▸ GRB2 ▸ PTK7 ▸
SYT1 ▸ HSP90AA1 ▸ STK36 ▸ STK19 ▸ ECM1 ▸ STK24 ▸ STK10 ▸
FYN ▸ STK3 ▸ FOSL1 ▸ SMAD5 ▸ FGF21 ▸ PLA2G1B ▸ CXCL11 ▸
IL7 ▸ EPO ▸ INSR ▸ GYS1 ▸ PTK6 ▸ STK4 ▸ CSF1 ▸
STK38 ▸ GDNF ▸ NFKBIA ▸ SLC22A3 ▸ WNK1 ▸ SMAD1 ▸ BCL3 ▸
BCL5 ▸ STK35 ▸ MET ▸ LCK ▸ PLCG2 ▸ NTRK1 ▸ STK11 ▸
STK16 ▸ CA2 ▸ PIP ▸ STK39 ▸ BTK ▸ TGFB2 ▸ RICTOR ▸
STK33 ▸ KITLG ▸ GYS2 ▸ BCL9 ▸ IL18 ▸ PDLIM7 ▸ STK40 ▸
STK31 ▸ SMAD4 ▸ LPA ▸ BCL6 ▸ IL13 ▸ SERPINE1 ▸ ECM2 ▸
LGALS3 ▸ ITGB1 ▸ SMAD3 ▸ CD4 ▸ KIT ▸ IL5 ▸ CAT ▸
FGF22 ▸ F2RL1 ▸ MYC ▸ FGF6 ▸ FGF23 ▸ RBBP7 ▸ PBK ▸
ATP5O ▸ PLD3 ▸ GPR15 ▸ VAV1 ▸ TNFSF10 ▸ TPO ▸ HDAC3 ▸
PDE3B ▸ PDK1 ▸ CCNG1 ▸ IL24 ▸ ABCB1 ▸ ADORA3 ▸ FGF9 ▸
WNT4 ▸ RBBP4 ▸ RLN2 ▸ CDC73 ▸ FGF12 ▸ PLD5 ▸ IL32 ▸
FGF13 ▸ PIK3CG ▸ FGF8 ▸ ADORA1 ▸ ODC1 ▸ FASLG ▸ CCND2 ▸
RNF19A ▸ PIK3IP1 ▸ SOAT1 ▸ NPY4R ▸ TNFSF13B ▸ BRAF ▸ CYP19A1 ▸
PPP1R3A ▸ FGF3 ▸ PLD6 ▸ HDAC1 ▸ AKT1S1 ▸ PPARG ▸ SMAD9 ▸
PLD1 ▸ SMAD6 ▸ PCNA ▸ CAV1 ▸ CXCL9 ▸ AR ▸ HDAC2 ▸
FGF14 ▸ CAV3 ▸ RUNX2 ▸ PAK2 ▸ STAT6 ▸ FGF18 ▸ BMP6 ▸
SHC1 ▸ RLN1 ▸ PLD4 ▸ BPNT1 ▸ FGF10 ▸ IL1A ▸ EGR1 ▸
RLN3 ▸ SPP1 ▸ EHMT1 ▸ CAV2 ▸ CTLA4 ▸ PAK1 ▸ TAT ▸
BAD ▸ FGF16 ▸ FGF20 ▸ PLA2G4A ▸ FGF7 ▸ FGF17 ▸ FGF1 ▸
SMAD7 ▸ FGF11 ▸ HSPB1 ▸ ERBB2 ▸ FGF19 ▸ FGF5 ▸ CALM3 ▸
SGK1 ▸ GAB2 ▸ CXCR4 ▸ NTRK2 ▸ SGK3 ▸ IL11 ▸ FGF4 ▸
NANOG ▸ GSK3A ▸ NA ▸ GPR62 ▸ CALM2 ▸ ITIH4 ▸ TFRC ▸
GPR125 ▸ GPR155 ▸ CALM1 ▸ CD19 ▸ GPR75 ▸ ARAF ▸ CSF2 ▸
PREX1 ▸ MT3 ▸ GPR27 ▸ GPR176 ▸ GRP ▸ GPR146 ▸ FGFR2 ▸
FGR ▸ GPR39 ▸ RBL2 ▸ ICOS ▸ GPR68 ▸ NCF1 ▸ IL31 ▸
ARSK ▸ ITGB4 ▸ ERBB4 ▸ NM ▸ BMP4 ▸ GPR161 ▸ GPR25 ▸
GPER1 ▸ CHKA ▸ IL27 ▸ GPR179 ▸ BMP7 ▸ MUC1 ▸ PGP ▸
GPR20 ▸ GPR133 ▸ LIF ▸ SOCS3 ▸ GPR150 ▸ HMGB1 ▸ IL16 ▸
GPR142 ▸ CCK ▸ GPR84 ▸ AGTR2 ▸ SNAI2 ▸ IFNB1 ▸ GPR98 ▸
CDC26 ▸ WNT3 ▸ BMP10 ▸ IL33 ▸ RPL17 ▸ CD14 ▸ DDIT3 ▸
PAK6 ▸ IL22 ▸ GPR148 ▸ GPR31 ▸ GPR34 ▸ GPR3 ▸ C1orf228 ▸
PAK7 ▸ MAP3K7 ▸ UVRAG ▸ LTB ▸ GPR182 ▸ CSE ▸ GPR119 ▸
NTRK3 ▸ AQP3 ▸ GPR123 ▸ GPR158 ▸ WNT2 ▸ MYCN ▸ GPR143 ▸
TGFB3 ▸ SLC9A1 ▸ BMP3 ▸ GTPBP1 ▸ GPR116 ▸ IL21 ▸ GPR21 ▸
GPR83 ▸ MUC8 ▸ GPR56 ▸ IKBKB ▸ CCL2 ▸ GPR78 ▸ GPR37 ▸
CDH5 ▸ NFAT5 ▸ TBL1X ▸ GPR156 ▸ PKD3 ▸ BRCA1 ▸ GPR160 ▸
IL34 ▸ GPR19 ▸ GPR12 ▸ IRS4 ▸ GPR32 ▸ LDLR ▸ GPR52 ▸
SLPI ▸ GPR128 ▸ CXCL10 ▸ CD86 ▸ GPR17 ▸ CDC37 ▸ TYR ▸
ANG ▸ GPR113 ▸ PKD2 ▸ E2F1 ▸ IL6ST ▸ IL9 ▸ WNT1 ▸
GPR152 ▸ GPR64 ▸ IL15 ▸ GPR4 ▸ CEBPB ▸ GPR115 ▸ ITGA5 ▸
SMN1 ▸ GPR79 ▸ GPR124 ▸ BMP5 ▸ TRNAE1 ▸ HBEGF ▸ CEBPA ▸
GPR85 ▸ IL25 ▸ GPR153 ▸ PKD1 ▸ GPR137 ▸ GPR180 ▸ MYOG ▸
GPR183 ▸ GPR173 ▸ GPR114 ▸ GPR101 ▸ DAB2IP ▸ IL37 ▸ NTF3 ▸
RHEB ▸ CD2 ▸ NOTCH1 ▸ CORO2A ▸ BMP15 ▸ PAK3 ▸ GPR135 ▸
PSEN1 ▸ GPR97 ▸ GPR1 ▸ CCDC88A ▸ CDC34 ▸ GPR141 ▸ FOXP3 ▸
IL26 ▸ GPR132 ▸ CDC7 ▸ LYN ▸ ADRBK1 ▸ GAPDH ▸ CDC6 ▸
PTGES ▸ UCN ▸ CHUK ▸ GPR108 ▸ GPS2 ▸ PLEK ▸ CDC45 ▸
GPR26 ▸ TBL1XR1 ▸ CDC20 ▸ WNT6 ▸ GPR174 ▸ BSG ▸ GPR126 ▸
CDK5 ▸ GPR6 ▸ PTH ▸ NCF4 ▸ ABL1 ▸ SKP2 ▸ GPR162 ▸
CDC23 ▸ VEGFC ▸ GPR18 ▸ RAE1 ▸ IRF1 ▸ GPR63 ▸ BMP1 ▸
WNT16 ▸ CDC27 ▸ DAB1 ▸ SIRT1 ▸ PRKCZ ▸ ADAM12 ▸ GPR82 ▸
GPR33 ▸ GDF15 ▸ GPR87 ▸ CDC123 ▸ GPR88 ▸ NFE2L2 ▸ GPR171 ▸
GPR107 ▸ GNE ▸ MSC ▸ TSC2 ▸ GPR149 ▸ MOK ▸ GPR157 ▸
MAP3K5 ▸ PTTG1 ▸ CDC16 ▸ MDM2 ▸ GPR65 ▸ GPR151 ▸ PAK4 ▸
GPR144 ▸ SST ▸ IGFBP3 ▸ IL20 ▸ GPR139 ▸ NCOR1 ▸ GPR61 ▸
WNT11 ▸ CDC40 ▸ GPR35 ▸ ITGA6 ▸ IL19 ▸ PDX1 ▸ PLAT ▸
GPR110 ▸ NRG1 ▸ GPR50 ▸ IL1RN ▸ PRDX2 ▸ CD38 ▸ GPR55 ▸
GPR42 ▸ BIRC2 ▸ GPR111 ▸ CPOX ▸ GPR112 ▸ GPR36 ▸ GPR22 ▸
GPR45 ▸ CX3CL1 ▸ RPS2 ▸ RPS5 ▸ PHLDA1 ▸ GNG3 ▸ GNAQ ▸
ITGB3 ▸ EEF1A1 ▸ SLC9A3R1 ▸ MYH9 ▸ NRAS ▸ GNG4 ▸ ATP1A1 ▸
UFD1L ▸ HNRNPA3 ▸ PGAM4 ▸ KLRD1 ▸ TUBB ▸ MRPS14 ▸ EFNA1 ▸
HIST1H2AD ▸ ACTBL2 ▸ IL2RB ▸ NPHS1 ▸ DHX15 ▸ HIST1H4A ▸ RASGRP3 ▸
IGLC7 ▸ HLA-DRA ▸ PPP1CB ▸ HNRNPAB ▸ GABRB1 ▸ IGHG2 ▸ CD80 ▸
UBTF ▸ SPTA1 ▸ GNG10 ▸ ITGAV ▸ PCBP1 ▸ IL1R1 ▸ SHC3 ▸
HRNR ▸ PIK3R3 ▸ HIST2H2BE ▸ ITIH1 ▸ IGLC3 ▸ RPLP1 ▸ PIK3C2B ▸
GRIN2B ▸ ACTA2 ▸ CANX ▸ NKRF ▸ DDX5 ▸ RPS12 ▸ TUBA1A ▸
RPL28 ▸ HIST1H2AH ▸ MYH14 ▸ GNG8 ▸ XRN2 ▸ RALY ▸ HIST1H2BB ▸
FCGR3B ▸ HNRNPH1 ▸ SH3KBP1 ▸ DHX30 ▸ TIAM2 ▸ EFNB2 ▸ PIP4K2A ▸
TXK ▸ IL23A ▸ SOS1 ▸ F11R ▸ HIST1H2AG ▸ FRS2 ▸ EIF2AK1 ▸
MS4A2 ▸ PABPN1 ▸ IL3RA ▸ HIST1H2BN ▸ PRDX6 ▸ MAP2K2 ▸ FIGF ▸
HNRNPDL ▸ GNG11 ▸ PIK3R5 ▸ AMPH ▸ GNB4 ▸ PGAM1 ▸ ARHGEF1 ▸
IL1RAP ▸ CD3Z ▸ IGF2BP2 ▸ FCER1G ▸ DDX3X ▸ HIST1H1T ▸ ZMYM2 ▸
RPS3 ▸ IGKC ▸ INS-IGF2 ▸ IL5RA ▸ SEMG2 ▸ HLA-B ▸ PIP4K2C ▸
EIF5A2 ▸ APLP2 ▸ RPLP0P6 ▸ FUS ▸ YWHAE ▸ PTCD3 ▸ ALDOA ▸
VAV2 ▸ CSF1R ▸ EEF2 ▸ HIST1H2BD ▸ GNA14 ▸ ACTG2 ▸ GH1 ▸
RUVBL1 ▸ IGLC1 ▸ PCID2 ▸ SEMG1 ▸ KIRREL ▸ RPS10 ▸ HIST1H2AE ▸
MYL6 ▸ PIP5K1C ▸ GNAI2 ▸ HIST3H2BB ▸ ITK ▸ SYNJ2 ▸ MRPS22 ▸
PGF ▸ MOV10 ▸ APPL1 ▸ LRPPRC ▸ TEK ▸ UBC ▸ MRAS ▸
NPHS2 ▸ TRA@ ▸ IGF2BP1 ▸ HIST1H2BM ▸ PIK3R4 ▸ RPS18 ▸ DNM1L ▸
PDE4D ▸ HNRNPC ▸ IGHG4 ▸ KL ▸ FCGR3A ▸ DDX17 ▸ EEF1A2 ▸
GFRA1 ▸ PRKRA ▸ GNG12 ▸ GNG7 ▸ ZAP70 ▸ SLC25A5 ▸ TREM2 ▸
GNB1 ▸ HIST2H2BF ▸ AP1M2 ▸ ABI1 ▸ RPLP0 ▸ PABPC1 ▸ PTPN1 ▸
RPS4X ▸ PGK1 ▸ EPB41L1 ▸ IL4R ▸ UNC5B ▸ YWHAQ ▸ PGR ▸
KLRC2 ▸ HNRNPR ▸ PPP1CA ▸ CUX1 ▸ PLCE1 ▸ SNRPF ▸ CKB ▸
INPP5E ▸ ATP5B ▸ GNB3 ▸ PLCD4 ▸ HCST ▸ CBLB ▸ TUBA1C ▸
FTL ▸ PRKCI ▸ RPL22 ▸ SYNCRIP ▸ YWHAH ▸ CRKL ▸ ADAP1 ▸
GNA11 ▸ PIP5K1B ▸ EIF5AL1 ▸ DNAJB6 ▸ PLCD1 ▸ CPSF1 ▸ ADAR ▸
GNAI3 ▸ HNRNPUL1 ▸ MARCKS ▸ MRPS25 ▸ CBLC ▸ ANXA2 ▸ AIFM1 ▸
HIST1H2AJ ▸ GNAI1 ▸ OCRL ▸ PIK3R2 ▸ RRAS2 ▸ MIF ▸ IGHG1 ▸
BCAR1 ▸ STAT5B ▸ VLDLR ▸ CD247 ▸ PIK3R6 ▸ MYO1C ▸ IFNGR1 ▸
LDHB ▸ CSF2RB ▸ CCAR2 ▸ HNRNPH3 ▸ CALR ▸ PDGFRA ▸ ANGPT1 ▸
FGFR1OP ▸ RHOG ▸ FES ▸ YBX3 ▸ B2M ▸ HIST1H1A ▸ DLG1 ▸
ATR ▸ IGHG3 ▸ GHR ▸ PABPC4 ▸ KLB ▸ CSF2RA ▸ CTNNA1 ▸
MATR3 ▸ PAICS ▸ ILF2 ▸ NPM1 ▸ NR3C1 ▸ PDPK1 ▸ SH2D2A ▸
IL2RG ▸ MRPS27 ▸ H2BFS ▸ HIST2H2AA3 ▸ RPS20 ▸ IGKV4-1 ▸ SQSTM1 ▸
RTCB ▸ EEF1A1P5 ▸ FCER1A ▸ MRPS23 ▸ PLCB3 ▸ ILF3 ▸ PCBP2 ▸
ERH ▸ PTMA ▸ GSN ▸ TIMM50 ▸ NEDD9 ▸ RPS24 ▸ PGAM2 ▸
SLC25A31 ▸ HNRNPA0 ▸ TRIM21 ▸ SGK2 ▸ MRPS28 ▸ SHC2 ▸ YES1 ▸
SHANK3 ▸ INPP5B ▸ RPSA ▸ EPS8 ▸ ATP1A3 ▸ GNAO1 ▸ GNG2 ▸
MRPL12 ▸ Il7r ▸ PPIA ▸ HIST1H2BO ▸ CCT5 ▸ VARS2 ▸ MYH10 ▸
IGLC6 ▸ HNRNPD ▸ IGLC2 ▸ HNRNPA1 ▸ RPS11 ▸ HIST1H2BK ▸ PIP5K1A ▸
NGFB ▸ WDR5 ▸ YWHAZ ▸ HIST2H2AC ▸ MRPS34 ▸ PPP1CC ▸ SNRPD3 ▸
BASP1 ▸ HNRNPF ▸ WDR6 ▸ H2AFJ ▸ RASD2 ▸ MDH2 ▸ C14orf166 ▸
SYNJ1 ▸ IL12RB1 ▸ FBL ▸ PCBP3 ▸ DGKZ ▸ MRPS26 ▸ PIK3C2A ▸
HLA-E ▸ GNB5 ▸ EIF5A ▸ TUBB4B ▸ SLC25A3 ▸ MRPS17 ▸ YWHAG ▸
FLT3 ▸ ALYREF ▸ DNAJB11 ▸ S100A10 ▸ GNGT2 ▸ FLT1 ▸ HIST1H2BJ ▸
SMO ▸ HIST1H2AB ▸ EDG1 ▸ IGHE ▸ IGF2BP3 ▸ PTBP1 ▸ DDX3Y ▸
RBMX ▸ HNRNPL ▸ FLNB ▸ NEFH ▸ GNB2 ▸ HIST2H2AA4 ▸ INSRR ▸
PLCZ1 ▸ SLC25A4 ▸ GNA15 ▸ CNTRL ▸ HNRNPA2B1 ▸ IL23R ▸ RPL23 ▸
PLCB2 ▸ HNRNPK ▸ PIK3C2G ▸ TPI1 ▸ IGKV1-5 ▸ PON2 ▸ KLRK1 ▸
PIK3AP1 ▸ DHX9 ▸ HIST1H2AC ▸ LGALS3BP ▸ ATXN2L ▸ HIST1H2BH ▸ ENY2 ▸
TRAT1 ▸ FGG ▸ HLA-DRB1 ▸ HIST1H2BL ▸ MASP1 ▸ HNRNPU ▸ ENO1 ▸
NBPF8 ▸ HLA-A ▸ FGA ▸ GNGT1 ▸ AMBP ▸ ITGB2 ▸ DNAJA1 ▸
KHDRBS1 ▸ LAT2 ▸ VAV3 ▸ FCGR1A ▸ TRIM24 ▸ TYROBP ▸ UPF1 ▸
GNG5 ▸ HNRNPH2 ▸ TRB@ ▸ SSR1 ▸ EPHB1 ▸ HIST3H2A ▸ JUP ▸
RUVBL2 ▸ PLCB1 ▸ GNG13 ▸ ATPIF1 ▸ ELAVL1 ▸ EPHB4 ▸ FGFR1OP2 ▸
PLCB4 ▸ LAT ▸ MRPS18B ▸ POTEKP ▸ PLCD3 ▸ STAU1 ▸ HSP90AB1 ▸
VEGF ▸ FGB ▸ TUBA4A ▸
Data information
Please see the Gene Interactions Track Manual.