Gene interactions and pathways from curated databases and text-mining
PIK3CA: top 25 interacting genes (chr3:178866310-178952497)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only PIK3CA-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
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Less-frequently mentioned interactions with PIK3CA, not among the Top 25
Other genes interacting with PIK3CA. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

EGF ▸ RAC1 ▸ EGFR ▸ IL6 ▸ NOS3 ▸ TNF ▸ MMP9 ▸
LEP ▸ IRS1 ▸ PTGS2 ▸ PI3 ▸ IL8 ▸ HMOX1 ▸ ANXA6 ▸
FOXO3 ▸ IRF6 ▸ CASP3 ▸ CASP9 ▸ CASP1 ▸ CASP10 ▸ BCR ▸
CASP6 ▸ BCL2 ▸ CASP2 ▸ CASP12 ▸ CASP5 ▸ CASP14 ▸ SRC ▸
CASP8 ▸ CASP7 ▸ CASP4 ▸ CASP16 ▸ GSK3B ▸ HIF1A ▸ JUN ▸
IL12A ▸ IL2 ▸ HGF ▸ IL12B ▸ IL10 ▸ FOXO1 ▸ NOS2 ▸
MLST8 ▸ CCND1 ▸ TLR4 ▸ FGF2 ▸ STAT3 ▸ CD28 ▸ NGF ▸
RAC2 ▸ CTNNB1 ▸ KRAS ▸ NOX4 ▸ TLR2 ▸ RAC3 ▸ RAF1 ▸
TP53 ▸ ESR1 ▸ NOX5 ▸ CBFA2T2 ▸ NOX3 ▸ PTPN11 ▸ BDNF ▸
IRS2 ▸ NOX1 ▸ MMP2 ▸ RHOA ▸ IL1B ▸ CREB5 ▸ CRK ▸
CDC42 ▸ MAP2K1 ▸ RPTOR ▸ ARHGEF7 ▸ HRAS ▸ CREB3 ▸ CREB1 ▸
JAK2 ▸ CD79A ▸ PRKAB2 ▸ IGF2 ▸ GRAP2 ▸ CDKN1A ▸ PRKAG2 ▸
PRKAA2 ▸ PRKAB1 ▸ CD79B ▸ PRKAG1 ▸ PRKAA1 ▸ PRKAR1B ▸ MMP14 ▸
GAB1 ▸ PRKAR1A ▸ PRKACB ▸ PRKAR2A ▸ MCL1 ▸ PRKAR2B ▸ PRKACG ▸
HSPG2 ▸ IFI27 ▸ BMP2 ▸ CBL ▸ SLC2A4 ▸ RAD50 ▸ PARP1 ▸
PLCG1 ▸ BCL10 ▸ SLC25A16 ▸ FOS ▸ FAS ▸ TLR5 ▸ SETD2 ▸
STAT1 ▸ IFNG ▸ SMAD2 ▸ PDGFB ▸ MRE11A ▸ PTK2 ▸ TCF7 ▸
MMP13 ▸ TCF20 ▸ PIK3R1 ▸ TERF2 ▸ IL3 ▸ PHKA2 ▸ JAK1 ▸
XRCC6 ▸ TCF23 ▸ PIK3CD ▸ IL4 ▸ CXCL12 ▸ PIK3CB ▸ RPS6KB1 ▸
TCF21 ▸ TLR3 ▸ MMP12 ▸ TCF25 ▸ MMP10 ▸ ESR2 ▸ TCF12 ▸
SYK ▸ XRCC5 ▸ TMED7 ▸ PDGFRB ▸ TERF2IP ▸ ACD ▸ TCF3 ▸
TCF4 ▸ XIAP ▸ TCF24 ▸ PRKCA ▸ AHSA1 ▸ TERF1 ▸ TCF15 ▸
TINF2 ▸ BAX ▸ IL17A ▸ TGFB1 ▸ POT1 ▸ MMP7 ▸ IGF1R ▸
TCF19 ▸ ANGPT2 ▸ PLD2 ▸ IKBKG ▸ CTGF ▸ RAB5A ▸ MMP21 ▸
TLR10 ▸ PLAU ▸ TLR8 ▸ MMP25 ▸ FOXO4 ▸ TLR6 ▸ MMP11 ▸
MMP26 ▸ MYLIP ▸ SLC2A1 ▸ SP1 ▸ TLR9 ▸ JAK3 ▸ MMP15 ▸
EIF4EBP1 ▸ MMP8 ▸ MMP19 ▸ SREBF1 ▸ VCAM1 ▸ ILK ▸ MMP24 ▸
MMP20 ▸ NOS1 ▸ FOXO6 ▸ ICAM1 ▸ MMP28 ▸ TLR7 ▸ MYD88 ▸
MMP17 ▸ PRL ▸ GJA1 ▸ MMP1 ▸ TLR1 ▸ MMP3 ▸ MMP16 ▸
ZGLP1 ▸ MMP27 ▸ IL7 ▸ STK40 ▸ BCL9 ▸ RICTOR ▸ NFKBIA ▸
PLCG2 ▸ NTRK1 ▸ IL18 ▸ SMAD5 ▸ STK11 ▸ BCL3 ▸ HSP90AA1 ▸
STK10 ▸ ECM2 ▸ SMAD4 ▸ MET ▸ CSF1 ▸ CDH1 ▸ GYS1 ▸
GRB2 ▸ STK35 ▸ BCL5 ▸ PLA2G1B ▸ PTK6 ▸ STK3 ▸ GDNF ▸
HRG ▸ CA2 ▸ SLC22A3 ▸ STK4 ▸ BCL6 ▸ INSR ▸ GYS2 ▸
STK38 ▸ STK24 ▸ KITLG ▸ BTK ▸ LPA ▸ PIP ▸ STK31 ▸
SERPINE1 ▸ TGFB2 ▸ STK16 ▸ STK33 ▸ SYT1 ▸ SMAD1 ▸ WNK1 ▸
PTK7 ▸ FGF21 ▸ STK19 ▸ FOSL1 ▸ STK39 ▸ STK25 ▸ EPO ▸
FYN ▸ LCK ▸ PDLIM7 ▸ CXCL11 ▸ IL13 ▸ STK36 ▸ ECM1 ▸
PAK1 ▸ AR ▸ PDE3B ▸ SHC1 ▸ FGF5 ▸ RBBP7 ▸ FGF11 ▸
FGF23 ▸ KIT ▸ ITGB1 ▸ FGF18 ▸ FGF13 ▸ CXCL9 ▸ FGF20 ▸
GSK3A ▸ PLD6 ▸ SPP1 ▸ PIK3IP1 ▸ BMP6 ▸ FGF8 ▸ ADORA1 ▸
CCNG1 ▸ PLD3 ▸ CAV1 ▸ HDAC2 ▸ FGF6 ▸ TAT ▸ EGR1 ▸
TPO ▸ IL32 ▸ PIK3CG ▸ FGF19 ▸ MYC ▸ PCNA ▸ ABCB1 ▸
IL24 ▸ SGK3 ▸ BAD ▸ CYP19A1 ▸ RLN1 ▸ AKT1S1 ▸ PAK2 ▸
CAV2 ▸ SMAD9 ▸ FGF9 ▸ PLD4 ▸ FASLG ▸ CDC73 ▸ FGF7 ▸
IL11 ▸ HDAC1 ▸ HDAC3 ▸ PLD1 ▸ PLD5 ▸ FGF4 ▸ NPY4R ▸
TNFSF13B ▸ RBBP4 ▸ F2RL1 ▸ IL5 ▸ GPR15 ▸ HSPB1 ▸ PLA2G4A ▸
RNF19A ▸ CTLA4 ▸ FGF16 ▸ CAV3 ▸ SMAD6 ▸ SGK1 ▸ EHMT1 ▸
FGF22 ▸ BPNT1 ▸ FGF3 ▸ IL1A ▸ PPARG ▸ SMAD3 ▸ NA ▸
SOAT1 ▸ GAB2 ▸ FGF12 ▸ VAV1 ▸ ODC1 ▸ ADORA3 ▸ STAT6 ▸
NANOG ▸ CXCR4 ▸ FGF10 ▸ RUNX2 ▸ PBK ▸ CCND2 ▸ FGF1 ▸
CALM3 ▸ ERBB2 ▸ TNFSF10 ▸ ATP5O ▸ CD4 ▸ NTRK2 ▸ FGF14 ▸
SMAD7 ▸ RLN2 ▸ FGF17 ▸ PDK1 ▸ LGALS3 ▸ RLN3 ▸ BRAF ▸
WNT4 ▸ CAT ▸ PPP1R3A ▸ GTPBP1 ▸ PREX1 ▸ LTB ▸ RBL2 ▸
DDIT3 ▸ GPR151 ▸ GPR158 ▸ CX3CL1 ▸ CSE ▸ GPR88 ▸ ITIH4 ▸
BIRC2 ▸ UCN ▸ GPR114 ▸ SIRT1 ▸ MUC8 ▸ GPR153 ▸ GPR179 ▸
GPR98 ▸ WNT16 ▸ GPR160 ▸ GPR33 ▸ PKD2 ▸ IFNB1 ▸ MDM2 ▸
IGFBP3 ▸ NM ▸ CDC34 ▸ HBEGF ▸ BSG ▸ ITGB4 ▸ PTH ▸
GPR125 ▸ CDK5 ▸ IL16 ▸ PRKCZ ▸ TFRC ▸ GPR156 ▸ LYN ▸
MT3 ▸ GDF15 ▸ FGFR2 ▸ SKP2 ▸ GPR35 ▸ PAK6 ▸ PAK3 ▸
GPR146 ▸ GPR32 ▸ GPR155 ▸ GNE ▸ GPR112 ▸ IL21 ▸ GPR56 ▸
MOK ▸ GPR152 ▸ CD2 ▸ NTF3 ▸ CPOX ▸ GPER1 ▸ MUC1 ▸
LDLR ▸ GPR176 ▸ PKD3 ▸ RAE1 ▸ CEBPA ▸ ITGA6 ▸ GPR115 ▸
GPR84 ▸ FOXP3 ▸ GPR143 ▸ IL34 ▸ GRP ▸ CALM2 ▸ E2F1 ▸
TBL1X ▸ PAK7 ▸ PTTG1 ▸ GPR79 ▸ IL26 ▸ GPR63 ▸ PDX1 ▸
GPR148 ▸ VEGFC ▸ SOCS3 ▸ CALM1 ▸ GPR144 ▸ GPR123 ▸ GPR64 ▸
CHKA ▸ CCL2 ▸ MYCN ▸ GPR20 ▸ CXCL10 ▸ NOTCH1 ▸ IL15 ▸
GPR142 ▸ TSC2 ▸ GPR126 ▸ MSC ▸ CDC40 ▸ LIF ▸ CDC20 ▸
CDC6 ▸ GPR119 ▸ GPR62 ▸ IL20 ▸ GPR68 ▸ SNAI2 ▸ PTGES ▸
BRCA1 ▸ GPR1 ▸ C1orf228 ▸ NFE2L2 ▸ NCF4 ▸ GPR6 ▸ IL9 ▸
PRDX2 ▸ GPS2 ▸ RPL17 ▸ IL6ST ▸ GPR110 ▸ GPR12 ▸ CDC7 ▸
GPR180 ▸ CD19 ▸ CDC23 ▸ GPR128 ▸ GPR107 ▸ GPR55 ▸ CEBPB ▸
BMP4 ▸ CDC45 ▸ GPR45 ▸ SST ▸ CDH5 ▸ GPR150 ▸ BMP3 ▸
IRS4 ▸ GPR137 ▸ WNT2 ▸ GPR27 ▸ SMN1 ▸ GPR162 ▸ BMP10 ▸
GPR42 ▸ ANG ▸ IKBKB ▸ GPR173 ▸ ABL1 ▸ AQP3 ▸ GPR161 ▸
IL1RN ▸ CD86 ▸ GPR22 ▸ GPR116 ▸ GPR65 ▸ IRF1 ▸ GPR34 ▸
ARAF ▸ GPR21 ▸ ITGA5 ▸ GPR75 ▸ CSF2 ▸ IL37 ▸ GPR36 ▸
GPR132 ▸ CORO2A ▸ GPR111 ▸ GPR78 ▸ MAP3K5 ▸ GPR157 ▸ GPR61 ▸
CD38 ▸ SLPI ▸ CHUK ▸ NRG1 ▸ ERBB4 ▸ ADRBK1 ▸ IL19 ▸
CDC27 ▸ GPR183 ▸ ICOS ▸ WNT11 ▸ GPR17 ▸ CCDC88A ▸ BMP1 ▸
AGTR2 ▸ GPR101 ▸ TRNAE1 ▸ BMP15 ▸ ARSK ▸ MAP3K7 ▸ GPR18 ▸
NFAT5 ▸ DAB2IP ▸ MYOG ▸ GPR139 ▸ PGP ▸ ADAM12 ▸ GPR141 ▸
GPR124 ▸ GPR108 ▸ CDC26 ▸ GPR26 ▸ CDC16 ▸ HMGB1 ▸ CD14 ▸
GPR182 ▸ GPR149 ▸ TBL1XR1 ▸ GPR52 ▸ WNT3 ▸ GPR82 ▸ IL33 ▸
SLC9A1 ▸ GAPDH ▸ GPR113 ▸ WNT1 ▸ NCF1 ▸ DAB1 ▸ RHEB ▸
NTRK3 ▸ GPR133 ▸ GPR19 ▸ GPR171 ▸ GPR37 ▸ CDC37 ▸ NCOR1 ▸
PAK4 ▸ CDC123 ▸ GPR135 ▸ GPR3 ▸ IL27 ▸ BMP5 ▸ GPR87 ▸
TGFB3 ▸ GPR83 ▸ GPR4 ▸ PLEK ▸ GPR25 ▸ IL22 ▸ GPR85 ▸
GPR31 ▸ PLAT ▸ GPR50 ▸ IL31 ▸ FGR ▸ TYR ▸ BMP7 ▸
IL25 ▸ PSEN1 ▸ GPR39 ▸ GPR174 ▸ UVRAG ▸ CCK ▸ PKD1 ▸
GPR97 ▸ WNT6 ▸ HIST1H2BJ ▸ LGALS3BP ▸ EEF1A1P5 ▸ YWHAG ▸ RASGRP3 ▸
AMPH ▸ XRN2 ▸ IL2RG ▸ RPS4X ▸ PPP1CC ▸ GNG13 ▸ PRDX6 ▸
ACTBL2 ▸ VAV2 ▸ EPB41L1 ▸ CCAR2 ▸ ANXA2 ▸ ILF2 ▸ GFRA1 ▸
IL5RA ▸ KLRK1 ▸ VARS2 ▸ EEF1A1 ▸ RPL22 ▸ SOS1 ▸ CD3Z ▸
FCGR3A ▸ PRKRA ▸ NEFH ▸ UPF1 ▸ FLT1 ▸ CPSF1 ▸ CALR ▸
CNTRL ▸ IL23A ▸ IGLC2 ▸ MDH2 ▸ PGAM1 ▸ PLCD4 ▸ PPIA ▸
GNAQ ▸ TIAM2 ▸ PABPC4 ▸ DDX3X ▸ ALDOA ▸ FCGR3B ▸ SLC9A3R1 ▸
RPS3 ▸ VEGF ▸ RTCB ▸ GNA14 ▸ PTPN1 ▸ PLCB1 ▸ MYH14 ▸
GNB3 ▸ ENO1 ▸ ACTG2 ▸ ADAR ▸ HLA-B ▸ FBL ▸ MRAS ▸
CTNNA1 ▸ HIST1H2AG ▸ FIGF ▸ MIF ▸ APPL1 ▸ MRPS34 ▸ PCBP3 ▸
PAICS ▸ INPP5B ▸ B2M ▸ SEMG1 ▸ F11R ▸ HIST1H2AC ▸ KLRC2 ▸
HIST1H2AH ▸ EIF5AL1 ▸ VAV3 ▸ FUS ▸ NPHS1 ▸ RPS20 ▸ MYL6 ▸
NPHS2 ▸ TRIM21 ▸ LAT2 ▸ PIP5K1C ▸ SLC25A31 ▸ ITGB3 ▸ ALYREF ▸
YWHAQ ▸ RPLP0P6 ▸ PLCE1 ▸ HIST2H2BE ▸ PIK3R2 ▸ YWHAE ▸ FCER1A ▸
MRPS22 ▸ GNG12 ▸ IL12RB1 ▸ GNAI3 ▸ PIK3C2G ▸ TRIM24 ▸ HNRNPH3 ▸
SMO ▸ INSRR ▸ MYH10 ▸ RASD2 ▸ EIF5A2 ▸ IL3RA ▸ FCGR1A ▸
HIST1H2BH ▸ EDG1 ▸ ITIH1 ▸ PIK3C2B ▸ UFD1L ▸ NRAS ▸ DHX30 ▸
JUP ▸ EPHB1 ▸ TREM2 ▸ HIST2H2BF ▸ OCRL ▸ UBTF ▸ GNAO1 ▸
ATPIF1 ▸ IGF2BP1 ▸ LDHB ▸ H2AFJ ▸ UNC5B ▸ HIST1H1T ▸ DDX5 ▸
RPS12 ▸ PABPN1 ▸ AP1M2 ▸ FGFR1OP2 ▸ GNG4 ▸ GNG5 ▸ CSF2RB ▸
IL4R ▸ PGF ▸ IGKV4-1 ▸ NKRF ▸ TXK ▸ ARHGEF1 ▸ PIK3R6 ▸
RPL23 ▸ IL23R ▸ BASP1 ▸ HIST1H2AJ ▸ PIP5K1B ▸ RPLP1 ▸ MRPS26 ▸
ATP1A1 ▸ S100A10 ▸ GNG3 ▸ GNG2 ▸ SNRPF ▸ APLP2 ▸ ATP1A3 ▸
MRPS23 ▸ PTCD3 ▸ EEF1A2 ▸ PLCD1 ▸ MRPS17 ▸ PABPC1 ▸ IGHG2 ▸
YES1 ▸ PIP4K2A ▸ Il7r ▸ NPM1 ▸ RALY ▸ PLCD3 ▸ RUVBL2 ▸
PCBP1 ▸ TPI1 ▸ DNAJB11 ▸ KL ▸ GABRB1 ▸ MASP1 ▸ HNRNPC ▸
TRA@ ▸ CUX1 ▸ FGG ▸ FES ▸ PTBP1 ▸ HNRNPL ▸ DNAJB6 ▸
HNRNPA2B1 ▸ HNRNPU ▸ DLG1 ▸ PIP5K1A ▸ ACTA2 ▸ PGR ▸ CANX ▸
HIST1H4A ▸ HIST2H2AA3 ▸ RPS2 ▸ STAU1 ▸ CKB ▸ FGB ▸ HIST1H2AE ▸
GNGT1 ▸ PIK3R3 ▸ EFNB2 ▸ IGHG3 ▸ EEF2 ▸ NGFB ▸ PIK3C2A ▸
HIST1H2BO ▸ HNRNPH1 ▸ GHR ▸ SPTA1 ▸ INPP5E ▸ WDR6 ▸ RPS24 ▸
SH2D2A ▸ HIST1H2BN ▸ IGLC7 ▸ PHLDA1 ▸ RPS11 ▸ ATR ▸ SEMG2 ▸
SHANK3 ▸ CRKL ▸ HIST1H2BM ▸ HNRNPA0 ▸ IGHE ▸ RPS18 ▸ HIST1H2BB ▸
ITGAV ▸ MYH9 ▸ ITK ▸ HIST3H2A ▸ CD247 ▸ MRPS25 ▸ MAP2K2 ▸
RPS10 ▸ PIP4K2C ▸ UBC ▸ GNAI2 ▸ TEK ▸ ANGPT1 ▸ HIST1H2BL ▸
PRKCI ▸ EPHB4 ▸ EIF2AK1 ▸ HIST1H2BD ▸ PIK3R4 ▸ EPS8 ▸ PTMA ▸
SLC25A3 ▸ ATXN2L ▸ KHDRBS1 ▸ HIST1H2AB ▸ PON2 ▸ HNRNPD ▸ MATR3 ▸
ITGB2 ▸ EIF5A ▸ SHC2 ▸ POTEKP ▸ KLB ▸ IGHG4 ▸ RBMX ▸
GNB1 ▸ SLC25A5 ▸ HNRNPDL ▸ HIST2H2AA4 ▸ SQSTM1 ▸ CBLB ▸ GNG7 ▸
RPS5 ▸ HNRNPA3 ▸ FLT3 ▸ IGKV1-5 ▸ MRPS18B ▸ ELAVL1 ▸ FTL ▸
TIMM50 ▸ H2BFS ▸ GNB2 ▸ HNRNPH2 ▸ ZMYM2 ▸ SH3KBP1 ▸ MRPS14 ▸
IL2RB ▸ IGLC1 ▸ MYO1C ▸ GH1 ▸ INS-IGF2 ▸ EFNA1 ▸ IL1R1 ▸
HLA-E ▸ NEDD9 ▸ HRNR ▸ MRPS28 ▸ TUBA1C ▸ PLCB4 ▸ ERH ▸
HLA-A ▸ YBX3 ▸ DNAJA1 ▸ IGLC6 ▸ GNA11 ▸ DHX9 ▸ PIK3AP1 ▸
IGLC3 ▸ PCBP2 ▸ HLA-DRA ▸ HIST1H2AD ▸ PGK1 ▸ HIST1H1A ▸ IGF2BP2 ▸
DNM1L ▸ HNRNPAB ▸ PDPK1 ▸ IGKC ▸ RPLP0 ▸ PLCB3 ▸ DHX15 ▸
GNAI1 ▸ GNB4 ▸ GNG8 ▸ TUBA1A ▸ IFNGR1 ▸ CSF2RA ▸ MRPL12 ▸
BCAR1 ▸ PGAM4 ▸ SLC25A4 ▸ HLA-DRB1 ▸ HNRNPF ▸ SYNCRIP ▸ SNRPD3 ▸
SHC3 ▸ FLNB ▸ CBLC ▸ C14orf166 ▸ PCID2 ▸ PPP1CB ▸ VLDLR ▸
NBPF8 ▸ GNGT2 ▸ SGK2 ▸ RPSA ▸ FRS2 ▸ HIST3H2BB ▸ PPP1CA ▸
SYNJ1 ▸ AIFM1 ▸ GNG10 ▸ DDX17 ▸ ABI1 ▸ CSF1R ▸ RUVBL1 ▸
AMBP ▸ TUBB ▸ CD80 ▸ HNRNPK ▸ ENY2 ▸ LAT ▸ ZAP70 ▸
IL1RAP ▸ MOV10 ▸ GSN ▸ DDX3Y ▸ STAT5B ▸ GNG11 ▸ RHOG ▸
SYNJ2 ▸ TRAT1 ▸ PLCB2 ▸ TUBA4A ▸ ILF3 ▸ PDGFRA ▸ IGHG1 ▸
PGAM2 ▸ TRB@ ▸ HNRNPUL1 ▸ FCER1G ▸ GNB5 ▸ HSP90AB1 ▸ NR3C1 ▸
RPL28 ▸ MRPS27 ▸ ADAP1 ▸ PIK3R5 ▸ CCT5 ▸ DGKZ ▸ LRPPRC ▸
FGFR1OP ▸ PDE4D ▸ SSR1 ▸ KLRD1 ▸ WDR5 ▸ FGA ▸ MS4A2 ▸
HNRNPR ▸ IGF2BP3 ▸ YWHAH ▸ GRIN2B ▸ TYROBP ▸ KIRREL ▸ HIST1H2BK ▸
RRAS2 ▸ TUBB4B ▸ ATP5B ▸ HCST ▸ YWHAZ ▸ HNRNPA1 ▸ GNA15 ▸
MARCKS ▸ HIST2H2AC ▸ PLCZ1 ▸
Data information
Please see the Gene Interactions Track Manual.