Gene interactions and pathways from curated databases and text-mining
IL6: top 25 interacting genes (chr7:22766765-22771621)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only IL6-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
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Less-frequently mentioned interactions with IL6, not among the Top 25
Other genes interacting with IL6. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

MAPK9 ▸ TLR4 ▸ IL17A ▸ IL3 ▸ TLR2 ▸ EPHB2 ▸ CSF2 ▸
IL13 ▸ TGFB1 ▸ CRP ▸ IL5 ▸ VEGFA ▸ IL21 ▸ IL18 ▸
TLR3 ▸ ICAM1 ▸ IL33 ▸ PTGS2 ▸ IL7 ▸ IL22 ▸ TLR9 ▸
CD40 ▸ FGB ▸ IL32 ▸ IL11 ▸ INS ▸ CCL2 ▸ IL15 ▸
IL19 ▸ JAK2 ▸ IL31 ▸ IL24 ▸ IL25 ▸ IL9 ▸ IL26 ▸
IL16 ▸ IL6ST ▸ IL34 ▸ JUN ▸ IL20 ▸ IL37 ▸ NOS2 ▸
IL27 ▸ SOCS3 ▸ TLR7 ▸ TLR1 ▸ TLR5 ▸ STAT1 ▸ TLR8 ▸
TLR10 ▸ TLR6 ▸ IL12B ▸ PTH ▸ SOAT1 ▸ SAA1 ▸ CSRP1 ▸
IL1RN ▸ AKT1 ▸ AKT3 ▸ FOS ▸ AKT2 ▸ JAK1 ▸ CD79A ▸
LEP ▸ LRPPRC ▸ IL12A ▸ VIP ▸ PIK3CA ▸ RNF19A ▸ PIK3R1 ▸
LTA ▸ CRK ▸ CD40LG ▸ CDC73 ▸ PTX3 ▸ ADCYAP1 ▸ LEO1 ▸
LIF ▸ PAF1 ▸ WDR61 ▸ CTR9 ▸ MMP1 ▸ PRKAB2 ▸ PRKAB1 ▸
IL6R ▸ PRKAG1 ▸ PRKAA2 ▸ PRKAG2 ▸ PRKAA1 ▸ FGF2 ▸ PTX4 ▸
GP5 ▸ HGF ▸ GP2 ▸ GP9 ▸ GP6 ▸ EDN1 ▸ MYLIP ▸
IGF1 ▸ MMP9 ▸ MMP3 ▸ TCF3 ▸ CRH ▸ GRAP2 ▸ JAK3 ▸
MMP2 ▸ TCF4 ▸ MYD88 ▸ TCF15 ▸ TCF20 ▸ TCF19 ▸ CISH ▸
TCF24 ▸ TCF21 ▸ TCF25 ▸ TCF23 ▸ TCF7 ▸ TCF12 ▸ CD4 ▸
IFNB1 ▸ MMP13 ▸ TGFB3 ▸ CA2 ▸ MCL1 ▸ A2M ▸ NOS3 ▸
PLG ▸ TGFB2 ▸ PAM ▸ TIMP1 ▸ AHSA1 ▸ OSM ▸ HP ▸
CD14 ▸ NOS1 ▸ PGF ▸ CEBPB ▸ HNRNPF ▸ PTBP1 ▸ HMGB1 ▸
HNRNPH1 ▸ PTBP2 ▸ CD46 ▸ CASP3 ▸ NFKBIA ▸ AR ▸ MT3 ▸
NA ▸ APOB ▸ STAT5A ▸ NOX4 ▸ CSF1 ▸ ALB ▸ PI3 ▸
PRG4 ▸ TAT ▸ PRG3 ▸ S100A12 ▸ PRG2 ▸ TNFSF11 ▸ NOX5 ▸
PRKAR1B ▸ NOX1 ▸ CASP12 ▸ CASP10 ▸ CASP8 ▸ NOX3 ▸ CASP7 ▸
CASP9 ▸ CASP5 ▸ CASP6 ▸ PRKACB ▸ CSF3 ▸ CASP1 ▸ PRKAR2B ▸
CASP4 ▸ CASP14 ▸ PRKAR1A ▸ PRKACG ▸ PRKAR2A ▸ NGF ▸ CASP16 ▸
CASP2 ▸ ANGPT2 ▸ FAS ▸ LPA ▸ SOCS1 ▸ ITIH4 ▸ POLDIP2 ▸
VCAM1 ▸ PRL ▸ FOXP3 ▸ MT4 ▸ GPI ▸ PDGFB ▸ SOD1 ▸
CALM3 ▸ FASLG ▸ SELE ▸ SOD3 ▸ MMP7 ▸ CD8A ▸ SYT1 ▸
SAA2 ▸ MMP10 ▸ CYP19A1 ▸ MMP11 ▸ MMP14 ▸ SPP1 ▸ CEBPA ▸
IRF1 ▸ PTPN11 ▸ PLA2G1B ▸ MMP8 ▸ SOD2 ▸ NUP43 ▸ BCL2 ▸
LBP ▸ HMOX1 ▸ IKBKB ▸ ANG ▸ APP ▸ MMP12 ▸ TNFRSF11B ▸
IFI44 ▸ HDAC1 ▸ MMP28 ▸ ADIPOQ ▸ MMP25 ▸ FCER2 ▸ SETBP1 ▸
MMP15 ▸ SERPINE1 ▸ ALG1 ▸ CCL3 ▸ CPOX ▸ MMP16 ▸ MMP26 ▸
EGF ▸ CALML3 ▸ MMP24 ▸ F2RL1 ▸ MMP17 ▸ MMP21 ▸ CTSB ▸
CD28 ▸ LPL ▸ NAALADL1 ▸ MMP20 ▸ MMP27 ▸ MMP19 ▸ CSK ▸
MSH3 ▸ FGF23 ▸ PPARG ▸ FGF1 ▸ FGF7 ▸ PRDX2 ▸ MAP3K7 ▸
NPS ▸ SAA4 ▸ TYR ▸ BCL3 ▸ FGF4 ▸ GH1 ▸ LTF ▸
MSH6 ▸ IRAK4 ▸ MIF ▸ ERVK-6 ▸ GFAP ▸ SERPINA3 ▸ PLA2G4A ▸
HES1 ▸ PTHLH ▸ IL23A ▸ AGTR2 ▸ HDAC2 ▸ BCL6 ▸ AGT ▸
PTPRC ▸ APC ▸ IL1R1 ▸ FGF20 ▸ FGF19 ▸ FGF12 ▸ CREB1 ▸
FGF9 ▸ SMAD3 ▸ PPARA ▸ CUL1 ▸ CREB3 ▸ LTB ▸ FGF21 ▸
TP53 ▸ FGF13 ▸ IGF2 ▸ CEACAM5 ▸ FGF10 ▸ FGF16 ▸ MTX1 ▸
FGF6 ▸ FGF8 ▸ PDLIM7 ▸ F2R ▸ KITLG ▸ SKP1 ▸ MSH5 ▸
FGF11 ▸ MSH4 ▸ IL2RA ▸ MSH2 ▸ FGF5 ▸ FGF22 ▸ IFNA2 ▸
CREB5 ▸ FGF14 ▸ FGF17 ▸ FGF18 ▸ FGF3 ▸ CHUK ▸ ABCC1 ▸
UCN ▸ HSPD1 ▸ PTK2 ▸ TRAF6 ▸ CEBPD ▸ HES3 ▸ IFNA7 ▸
MTOR ▸ EGFR ▸ MPO ▸ PTK6 ▸ MRXS5 ▸ HES6 ▸ TXN ▸
IFNA6 ▸ HES7 ▸ IFNA16 ▸ BMP2 ▸ CCL5 ▸ MAP2K1 ▸ CD44 ▸
IFNA10 ▸ IFNA14 ▸ CD8B ▸ EPO ▸ RHO ▸ IFNA5 ▸ IFNA4 ▸
HES4 ▸ IFNA1 ▸ IFNA21 ▸ IFNA8 ▸ HES5 ▸ SST ▸ HES2 ▸
ESR1 ▸ CDKN1A ▸ ANXA1 ▸ CXCL12 ▸ PTK7 ▸ IFNA13 ▸ IFNA17 ▸
SMAD2 ▸ CXCL1 ▸ RENBP ▸ RBBP7 ▸ CNTF ▸ STAT4 ▸ MUC1 ▸
IKBKG ▸ FCGR1A ▸ PRKCA ▸ HSPB1 ▸ NAMPT ▸ CXCL10 ▸ NPY ▸
CAV2 ▸ RBBP4 ▸ C4BPA ▸ SP1 ▸ CAV1 ▸ CAV3 ▸ KLK3 ▸
MAP2K4 ▸ PAEP ▸ SMAD7 ▸ SMAD4 ▸ P2RX7 ▸ IDO1 ▸ WNK1 ▸
BAX ▸ CNTN2 ▸ ANPEP ▸ TFPI ▸ HAMP ▸ AVP ▸ HDC ▸
ADCY4 ▸ SMAD6 ▸ CD86 ▸ AGTR1 ▸ SIN3A ▸ SRC ▸ TAB1 ▸
IRS1 ▸ ADCY6 ▸ ADCY1 ▸ PDCD11 ▸ NPPA ▸ HIF1A ▸ MUC4 ▸
NOD1 ▸ IRF3 ▸ IRAK1 ▸ MBP ▸ DUSP1 ▸ GIF ▸ CLEC7A ▸
ADCY9 ▸ CYP3A4 ▸ MET ▸ JUND ▸ SMAD5 ▸ S100B ▸ CD5 ▸
RAG2 ▸ CAT ▸ NPEPPS ▸ ARID4B ▸ ADCY10 ▸ TNFRSF1A ▸ IL17RA ▸
ADCY3 ▸ CSE ▸ HLA-DRA ▸ ADM ▸ TNFRSF1B ▸ HLA-DRB1 ▸ NOD2 ▸
SELP ▸ SHC1 ▸ WNT5A ▸ SUDS3 ▸ ADCY8 ▸ TGFA ▸ SMAD1 ▸
CORT ▸ ADCY2 ▸ BCL10 ▸ GZMB ▸ RAG1 ▸ ACE ▸ DDIT3 ▸
BMP7 ▸ ADCY7 ▸ SMAD9 ▸ CHAT ▸ ACP2 ▸ STS ▸ SAP130 ▸
IFI27 ▸ SELL ▸ SAP30 ▸ ADCY5 ▸ BMP6 ▸ NM ▸ SYK ▸
REL ▸ GCG ▸ CCR5 ▸ IL17D ▸ IRF4 ▸ PGP ▸ PIGA ▸
CR2 ▸ ICAM5 ▸ S100A9 ▸ ZFP36 ▸ MUC20 ▸ RETN ▸ ATP8A2 ▸
ST2 ▸ PTPN4 ▸ S100A8 ▸ EIF2AK2 ▸ TNFRSF8 ▸ HSF1 ▸ MUC22 ▸
CYP3A ▸ CCL20 ▸ HRAS ▸ ICAM4 ▸ BCL9 ▸ CTGF ▸ BMP1 ▸
NLRP3 ▸ MUC17 ▸ UTP18 ▸ PDGFA ▸ BTRC ▸ IRAK3 ▸ INA ▸
TPO ▸ MPG ▸ IGFBP1 ▸ IL17F ▸ APOE ▸ IBD8 ▸ OPRM1 ▸
CTSL ▸ SETD2 ▸ ANXA6 ▸ ARSA ▸ CYP1A1 ▸ ICOSLG ▸ MUC16 ▸
TF ▸ SFTPC ▸ ICAM3 ▸ MAP2K7 ▸ MUC21 ▸ IBD6 ▸ CCND1 ▸
UTP15 ▸ UTP3 ▸ ABCB1 ▸ AHR ▸ MAP2K3 ▸ FGFR3 ▸ CXCL17 ▸
PLD1 ▸ ADORA1 ▸ HMGCR ▸ IBD2 ▸ PTGS1 ▸ HSP90AB1 ▸ TYK2 ▸
MUC12 ▸ IBD4 ▸ CTF1 ▸ EDN2 ▸ MUC2 ▸ LGALS1 ▸ TNFSF13B ▸
IBD5 ▸ UTP20 ▸ IBD3 ▸ MUC15 ▸ EDN3 ▸ IBD9 ▸ VAV1 ▸
HSPG2 ▸ MUC8 ▸ GRB2 ▸ MUC6 ▸ SEA ▸ MAP2K6 ▸ MAP2K5 ▸
UTP6 ▸ PLD2 ▸ MUC19 ▸ ATF3 ▸ NCAM1 ▸ MUC7 ▸ REG1A ▸
ICAM2 ▸ MAP2K2 ▸ POMC ▸ IBD7 ▸ MUC13 ▸ PPP2CA ▸ MOG ▸
UTP23 ▸ BCL5 ▸ ITGB1 ▸ PARP6 ▸ CLU ▸ GHRH ▸ NEUROD2 ▸
EPX ▸ TEC ▸ CXCR4 ▸ HPD ▸ FXYD1 ▸ FXR2 ▸ CTSS ▸
NDP ▸ TRAF2 ▸ TGM2 ▸ GTF2B ▸ SERPINF1 ▸ IRF9 ▸ ETS1 ▸
MAPKAPK2 ▸ WNT4 ▸ IRF5 ▸ PPP2R2B ▸ BMP15 ▸ PON1 ▸ NNMT ▸
CCL1 ▸ IL1R2 ▸ ABL1 ▸ CPB1 ▸ GPX7 ▸ UCN2 ▸ GPX2 ▸
PPP2R1A ▸ HSPB3 ▸ ANGPT1 ▸ SCARB1 ▸ PGD ▸ CSH2 ▸ HCL2 ▸
PARP3 ▸ NTF3 ▸ CD2 ▸ CX3CR1 ▸ ETS2 ▸ GAL ▸ ROR1 ▸
FUT4 ▸ GPX1 ▸ PIM1 ▸ OAS3 ▸ CD80 ▸ AHSG ▸ GNRH1 ▸
ADORA3 ▸ WNT10B ▸ MPL ▸ HCL3 ▸ THBD ▸ XBP1 ▸ DNMT1 ▸
ITGAM ▸ PLD6 ▸ TNPO1 ▸ MS4A1 ▸ GPX6 ▸ KNG1 ▸ PARP11 ▸
PARK2 ▸ GYS2 ▸ HCK ▸ IGFBP3 ▸ CD163 ▸ C1QA ▸ EPS8 ▸
HSP90AA1 ▸ PDCD4 ▸ BMP5 ▸ HDAC3 ▸ CA1 ▸ XRCC1 ▸ HSPA5 ▸
CXCL6 ▸ SLPI ▸ PARP16 ▸ PARP8 ▸ EPS15 ▸ ATP7A ▸ PLD3 ▸
PARP4 ▸ PARP9 ▸ NEUROD4 ▸ NEUROD6 ▸ GPX8 ▸ NFATC2 ▸ RPL17 ▸
TSLP ▸ C5AR1 ▸ PITX2 ▸ IDS ▸ GPX5 ▸ PARP15 ▸ TIMP2 ▸
FXR1 ▸ PLD5 ▸ BGLAP ▸ OAS2 ▸ PCK1 ▸ CYP1A2 ▸ BTK ▸
IRF8 ▸ GYS1 ▸ CD1D ▸ CRYGEP ▸ CD19 ▸ PARP2 ▸ C1orf228 ▸
BMP10 ▸ ATP5O ▸ FOXO3 ▸ GPX4 ▸ GPX3 ▸ BMP3 ▸ PARP1 ▸
OPN1LW ▸ CHGA ▸ GNA13 ▸ PARP14 ▸ MAF ▸ PLD4 ▸ OAS1 ▸
LYN ▸ HCL1 ▸ PARP10 ▸ ACHE ▸ CIB1 ▸ HDAC6 ▸ EBP ▸
TRPV1 ▸ LCN2 ▸ PTS ▸ C1QB ▸ BPI ▸ NEUROD1 ▸ ESR2 ▸
BCR ▸ CPB2 ▸ BMP4 ▸ PARP12 ▸ TRNAI1 ▸ CDH1 ▸ CXCL5 ▸
STK38 ▸ FLT3LG ▸ TRD ▸ HSPB8 ▸ SP3 ▸ CXCL3 ▸ TGM4 ▸
MKL1 ▸ TBCC ▸ MEPE ▸ IRG1 ▸ CCR2 ▸ RUNX2 ▸ MCS ▸
TIRAP ▸ ECM1 ▸ SERPINB5 ▸ GSTM3 ▸ P2RY6 ▸ ICOS ▸ STK39 ▸
ADH4 ▸ RLN3 ▸ TNFAIP6 ▸ DERL1 ▸ CDKN1B ▸ ABCG2 ▸ CD38 ▸
ATF4 ▸ FMR1 ▸ ACR ▸ CALM2 ▸ DYNLRB1 ▸ ADH6 ▸ OXA1L ▸
KDR ▸ CDK4 ▸ COQ2 ▸ SMN1 ▸ SMC5 ▸ BSG ▸ IL2RB ▸
SCG5 ▸ TFAP2A ▸ PDAP1 ▸ NTF4 ▸ KRT13 ▸ SERPINA6 ▸ RLN2 ▸
TRAF1 ▸ MAL ▸ TIMP3 ▸ STK35 ▸ AREG ▸ COQ3 ▸ CXCL11 ▸
MAP3K3 ▸ TBP ▸ RORC ▸ HDAC4 ▸ HDAC11 ▸ COL1A1 ▸ NPY4R ▸
NTS ▸ AD5 ▸ IGFBP4 ▸ MICE ▸ CXCL14 ▸ MUC5AC ▸ CRAT ▸
IRF7 ▸ SARS ▸ ITGA4 ▸ ACAN ▸ PDCD5 ▸ RB1 ▸ TSC22D3 ▸
MYO6 ▸ ARG1 ▸ ACE2 ▸ HDAC9 ▸ ACSM3 ▸ RPS6KA3 ▸ SERPING1 ▸
STK24 ▸ SLC39A14 ▸ PLAT ▸ EGR1 ▸ MYO16 ▸ FGFR2 ▸ ATF1 ▸
CD1C ▸ ROR2 ▸ THBS1 ▸ DEFB4B ▸ IGFBP5 ▸ AMELX ▸ STK25 ▸
FLOT2 ▸ GAST ▸ ADH5 ▸ CD33 ▸ AIF1 ▸ RBP4 ▸ CCR1 ▸
XIAP ▸ C5 ▸ STK19 ▸ WNT11 ▸ GSTM4 ▸ CHP2 ▸ SAA3P ▸
BAI3 ▸ TNFSF10 ▸ MSC ▸ GCLC ▸ RAB7A ▸ GSTM1 ▸ MTA3 ▸
PDCD2 ▸ RNASE3 ▸ RLN1 ▸ KRT38 ▸ HDAC10 ▸ JUNB ▸ EEF1A2 ▸
CEACAM1 ▸ STK4 ▸ VWF ▸ PARK7 ▸ CXCL13 ▸ PTPN22 ▸ KLRB1 ▸
GAS6 ▸ ADH7 ▸ ITGA2B ▸ CXCL16 ▸ RAB7B ▸ VHLL ▸ SMC6 ▸
MYO19 ▸ CD69 ▸ ADIPOR1 ▸ NT5E ▸ SMC3 ▸ MIP ▸ CCK ▸
VCP ▸ NLRC5 ▸ STEAP4 ▸ STK33 ▸ STK3 ▸ WAS ▸ APOA4 ▸
UCN3 ▸ CD274 ▸ PRNP ▸ EREG ▸ BLVRB ▸ CCR6 ▸ IGF1R ▸
LRG1 ▸ WNT1 ▸ MTA2 ▸ GSTM5 ▸ E2F1 ▸ GSTM2 ▸ P2RX1 ▸
SCG2 ▸ BAI2 ▸ LDLR ▸ STK10 ▸ CD34 ▸ ECM2 ▸ IL1RAP ▸
FYN ▸ HPX ▸ PHB ▸ NOTCH1 ▸ SMC4 ▸ CPA1 ▸ MCC ▸
TSN ▸ IFIT1 ▸ STK36 ▸ RABEPK ▸ PDCD1 ▸ OXTR ▸ PLA2G2D ▸
HDAC8 ▸ STK31 ▸ COQ7 ▸ CP ▸ WNT3 ▸ MTA1 ▸ HDAC5 ▸
IGFBP2 ▸ BAI1 ▸ CALM1 ▸ EDNRA ▸ LYZ ▸ PINK1 ▸ DEFB114 ▸
SERPINA1 ▸ TAC4 ▸ TRAF5 ▸ RAF1 ▸ WNT16 ▸ NANOG ▸ STK40 ▸
TRAF3IP2 ▸ HBD ▸ POU5F1 ▸ BDNF ▸ TAC3 ▸ SFTPA1 ▸ WNT2 ▸
SLC33A1 ▸ CALCA ▸ CX3CL1 ▸ PTK2B ▸ IGFBP7 ▸ CEBPZ ▸ ADAM17 ▸
FGL1 ▸ PIAS3 ▸ CCL4 ▸ COQ6 ▸ PSMB9 ▸ ACD ▸ STK11 ▸
REN ▸ SCG3 ▸ CXCR3 ▸ IRAK2 ▸ TAC1 ▸ MIA ▸ HDAC7 ▸
VIMP ▸ QRICH1 ▸ GIP ▸ IRF2 ▸ NTN1 ▸ PDCD7 ▸ CXCL2 ▸
QRICH2 ▸ SLC25A3 ▸ COQ9 ▸ TTR ▸ KRT37 ▸ PC ▸ HCFC1 ▸
TGM7 ▸ CDKN2A ▸ PPP5C ▸ WNT6 ▸ ASIP ▸ ARG2 ▸ C3AR1 ▸
NR0B1 ▸ NR4A1 ▸ PCK2 ▸ RAC1 ▸ TNC ▸ CHP1 ▸ KRT10 ▸
RASIP1 ▸ SOS1 ▸ ITGA5 ▸ STK16 ▸ AZU1 ▸ COQ4 ▸ IL2RG ▸
MYC ▸ SPN ▸ APCS ▸ COQ5 ▸ SERPINE2 ▸ NOTCH2 ▸ PDCD6 ▸
CXCL9 ▸ CREBBP ▸ ABCA4 ▸ SMC2 ▸ LCAT ▸ LGALS3 ▸ SDC1 ▸
ANGPT4 ▸ NMU ▸ CDK9 ▸ MYO10 ▸ CNR2 ▸ PDCD10 ▸ CD59 ▸
ZBTB16 ▸ KAT2B ▸ CBL ▸ HNRNPA1 ▸ GCSAM ▸ PTGER4 ▸ NFKB2 ▸
ERBB3 ▸ PRKD1 ▸ PTPRE ▸ SH3GL2 ▸ PIAS1 ▸ PIK3C3 ▸ MEOX2 ▸
F12 ▸ FOXO1 ▸
Data information
Please see the Gene Interactions Track Manual.