Radiat Res 1998,
PMID: 9611098
Jung, M; Zhang, Y; Dimtchev, A; Dritschilo, A
Recent studies have shown that activation of nuclear factor-kappaB (NF-kappaB) is critical for cell survival. Cells from patients with ataxia telangiectasia (AT) have an impaired NF-kappaB response to ionizing radiation. AT cells also exhibit inappropriate regulation of apoptosis. We report here that expression of a dominant negative form of IkappaB-alpha, an inhibitor of NF-kappaB, protects AT fibroblasts from apoptosis induced by gamma radiation, but it enhances apoptosis in normal fibroblasts. Furthermore, the process leading to apoptosis may involve caspase 3-mediated cleavage of IkappaB-alpha. These data suggest that regulation of NF-kappaB may play an important role in programmed cell death induced by DNA damage in AT cells.
Diseases/Pathways annotated by Medline MESH: Ataxia Telangiectasia
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Text Mining Data
NF-kappaB ⊣ IkappaB-alpha: "
We report here that expression of a dominant negative form of
IkappaB-alpha , an
inhibitor of
NF-kappaB , protects AT fibroblasts from apoptosis induced by gamma radiation, but it enhances apoptosis in normal fibroblasts
"
programmed cell death — NF-kappaB: "
These data suggest that regulation of NF-kappaB may play an important role in programmed cell death induced by DNA damage in AT cells
"
Manually curated Databases
No curated data.