J Biol Chem 1997,
PMID: 9388192
Zhang, Z; Jones, S; Hagood, J S; Fuentes, N L; Fuller, G M
Interleukin-6 (IL-6) and glucocorticoids are important mediators of inflammatory and immunological responses. Glucocorticoids are known to synergistically enhance IL-6-mediated cellular responses. We now show that IL-6 also has a synergistic effect upon glucocorticoid signaling. In particular, IL-6-activated STAT3 associates with ligand-bound glucocorticoid receptor to form a transactivating/signaling complex, which can function through either an IL-6-responsive element or a glucocorticoid-responsive element. These findings reveal a new level of interaction between these two crucial signaling cascades and indicate that activated STAT3 can also act as a transcriptional co-activator without direct association with its DNA binding motif.
Diseases/Pathways annotated by Medline MESH: Liver Neoplasms, Experimental
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Text Mining Data
Dashed line = No text mining data
Manually curated Databases
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IRef Biogrid Interaction:
STAT3
—
NR3C1
(physical association, affinity chromatography technology)
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IRef Hprd Interaction:
STAT3
—
NR3C1
(in vivo)
In total, 1 gene pairs are associated to this article in curated databases