Gene interactions and pathways from curated databases and text-mining
Mol Cell Biol 1995, PMID: 7791761

Activation of retinoid X receptors induces apoptosis in HL-60 cell lines.

Nagy, L; Thomázy, V A; Shipley, G L; Fésüs, L; Lamph, W; Heyman, R A; Chandraratna, R A; Davies, P J

Retinoids induce myeloblastic leukemia (HL-60) cells to differentiate into granulocytes, which subsequently die by apoptosis. Retinoid action is mediated through at least two classes of nuclear receptors: retinoic acid receptors, which bind both all-trans retinoic acid and 9-cis retinoic acid, and retinoid X receptors, which bind only 9-cis retinoic acid. Using receptor-selective synthetic retinoids and HL-60 cell sublines with different retinoid responsiveness, we have investigated the contribution that each class of receptors makes to the processes of cellular differentiation and death. Our results demonstrate that ligand activation of retinoic acid receptors is sufficient to induce differentiation, whereas ligand activation of retinoid X receptors is essential for the induction of apoptosis in HL-60 cell lines.

Diseases/Pathways annotated by Medline MESH: Leukemia
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Text Mining Data

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Manually curated Databases

  • NCI Pathway Database Retinoic acid receptors-mediated signaling: NRIP1 (NRIP1) → Erk1-2-active (MAPK3/MAPK1) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: NRIP1 (NRIP1) → RXRs/RARs/NRIP1/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NRIP1) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: NRIP1 (NRIP1) → RXRs/RARs complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: NRIP1 (NRIP1) → None (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: NRIP1 (NRIP1) → AKT1 (AKT1) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: NRIP1 (NRIP1) → SMRT (N-CoR2) (NCOR2) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: NRIP1 (NRIP1) → RXRs/RARs/SMRT(N-CoR2)/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NCOR2) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: Erk1-2-active (MAPK3/MAPK1) → RXRs/RARs/NRIP1/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NRIP1) (modification, activates)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: Erk1-2-active (MAPK3/MAPK1) → RXRs/RARs complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA) (modification, activates)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: Erk1-2-active (MAPK3/MAPK1) → None (modification, activates)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: Erk1-2-active (MAPK3/MAPK1) → AKT1 (AKT1) (modification, activates)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: Erk1-2-active (MAPK3/MAPK1) → SMRT (N-CoR2) (NCOR2) (modification, activates)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: Erk1-2-active (MAPK3/MAPK1) → RXRs/RARs/SMRT(N-CoR2)/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NCOR2) (modification, activates)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs/RARs/NRIP1/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NRIP1) → RXRs/RARs complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs/RARs/NRIP1/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NRIP1) → None (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs/RARs/NRIP1/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NRIP1) → SMRT (N-CoR2) (NCOR2) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs/RARs/NRIP1/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NRIP1) → RXRs/RARs/SMRT(N-CoR2)/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NCOR2) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs/RARs complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA) → None (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs/RARs complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA) → AKT1 (AKT1) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs/RARs complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA) → SMRT (N-CoR2) (NCOR2) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs/RARs complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA) → RXRs/RARs/SMRT(N-CoR2)/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NCOR2) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: None → AKT1 (AKT1) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: None → SMRT (N-CoR2) (NCOR2) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: None → RXRs/RARs/SMRT(N-CoR2)/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NCOR2) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: AKT1 (AKT1) → SMRT (N-CoR2) (NCOR2) (modification, activates)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: AKT1 (AKT1) → RXRs/RARs/SMRT(N-CoR2)/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NCOR2) (modification, activates)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database Retinoic acid receptors-mediated signaling: SMRT (N-CoR2) (NCOR2) → RXRs/RARs/SMRT(N-CoR2)/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NCOR2) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
In total, 62 gene pairs are associated to this article in curated databases